Yufang Shi
Soochow University (Suzhou)
334 Papers
1.7K Citations
Yufang Shi is an academic researcher from Soochow University (Suzhou). The author has contributed to research in topics: Mesenchymal stem cell & Immune system. The author has an hindex of 78, co-authored 285 publications. Previous affiliations of Yufang Shi include University of Alberta & Qingdao University.
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Papers
Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells
G Wang,Kai Cao,Keli Liu,Yueqing Xue,Arthur I. Roberts,Fengying Li,Yanyan Han,Arnold B. Rabson,Ying Wang,Yufang Shi,Yufang Shi +10 more
TL;DR: A novel link between IDO and TSG-6 is uncovered, and it is demonstrated that a metabolite of IDO controls the TSg-6-mediated anti-inflammatory therapeutic effects of human MSCs.
•Journal Article
In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes.
TL;DR: Findings on activation-induced apoptosis in vitro can be extended to the in vivo situation, and it is found that shortly after antibody injection, cortical thymocytes undergo apoptosis as characterized by morphologic changes and DNA fragmentation.
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CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation
TL;DR: It is reported that genetic inactivation of CD11b abolishes orally induced peripheral immune tolerance (oral tolerance) without compromising APC maturation or antigen-specific immune activation and concluded that CD 11b facilitates oral tolerance by suppressing Th17 immune differentiation.
TNFα-activated mesenchymal stromal cells promote breast cancer metastasis by recruiting CXCR2 + neutrophils
Pengfei Yu,Y Huang,Yanyan Han,Liangyu Lin,W. H. Sun,Arnold B. Rabson,Ying Wang,Yufang Shi,Yufang Shi,Yufang Shi +9 more
TL;DR: It is demonstrated that TNFα-activated MSCs promote tumor metastasis via CXCR2+ neutrophil recruitment, and genetic or pharmacological strategies to inhibit CCL5 or CCR2 ligands were indispensable in supporting TNF α-activation to promote tumors metastasis.
•Journal Article
CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response
Laszlo Radvanyi,Yufang Shi,Homayoun Vaziri,Ajay Sharma,Ruwaida Dhala,Gordon B. Mills,Gordon B. Mills,Richard G. Miller +7 more
TL;DR: The CD28 signaling pathway may function not only in the initial activation of naive T cells, but also in maintaining their viability and responsiveness during a primary immune response, with bcl-xL being perhaps more important in maintaining viability of activated T cells traversing the cell cycle.
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