Yuezhou Chen
Brigham and Women's Hospital
13 Papers
Yuezhou Chen is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Antibody & Medicine. The author has an hindex of 7, co-authored 8 publications.
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Papers
DNA vaccine protection against SARS-CoV-2 in rhesus macaques.
Jingyou Yu,Lisa H. Tostanoski,Lauren Peter,Noe B. Mercado,Katherine McMahan,Shant H. Mahrokhian,Joseph P. Nkolola,Jinyan Liu,Zhenfeng Li,Abishek Chandrashekar,David R. Martinez,Carolin Loos,Caroline Atyeo,Stephanie Fischinger,John S. Burke,Matthew D. Slein,Yuezhou Chen,Adam Zuiani,Felipe J.N. Lelis,Meghan Travers,Shaghayegh Habibi,Laurent Pessaint,Alex Van Ry,Kelvin Blade,Renita Brown,Anthony Cook,Brad Finneyfrock,Alan Dodson,Elyse Teow,Jason Velasco,Roland Zahn,Frank Wegmann,Esther A. Bondzie,Gabriel Dagotto,Makda S. Gebre,Xuan He,Catherine Jacob-Dolan,Marinela Kirilova,Nicole Kordana,Zijin Lin,Lori F. Maxfield,Felix Nampanya,Ramya Nityanandam,John D. Ventura,Huahua Wan,Yongfei Cai,Bing Chen,Aaron G. Schmidt,Duane R. Wesemann,Ralph S. Baric,Galit Alter,Hanne Andersen,Mark G. Lewis,Dan H. Barouch,Dan H. Barouch +54 more
TL;DR: Analysis of the vaccine candidates in rhesus macaques showed that animals developed protective humoral and cellular immune responses when challenged with the SARS-CoV-2 virus, suggesting an immune correlate of protection.
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Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity.
Ellen Shrock,Ellen Shrock,Eric Fujimura,Eric Fujimura,Tomasz Kula,Tomasz Kula,Richard T. Timms,Richard T. Timms,I-Hsiu Lee,Yumei Leng,Yumei Leng,Matthew L Robinson,Brandon M. Sie,Brandon M. Sie,Mamie Z. Li,Mamie Z. Li,Yuezhou Chen,Jennifer K. Logue,Adam Zuiani,Denise J. McCulloch,Felipe J.N. Lelis,Stephanie A. Henson,Daniel R. Monaco,Meghan Travers,Shaghayegh Habibi,William Clarke,Patrizio Caturegli,Oliver Laeyendecker,Oliver Laeyendecker,Alicja Piechocka-Trocha,Jonathan Z. Li,Ashok Khatri,Helen Y. Chu,Alexandra-Chloé Villani,Kyle R. Kays,Marcia B. Goldberg,Nir Hacohen,Michael R. Filbin,Xu G. Yu,Bruce D. Walker,Bruce D. Walker,Duane R. Wesemann,H. Benjamin Larman,James A. Lederer,Stephen J. Elledge,Stephen J. Elledge +45 more
TL;DR: A systematic characterization of the humoral response to severe acute respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed, important for understanding the immunogenicity of the viral proteome and the basis for cross-reactivity with the common-cold coronaviruses.
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Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women
Christina Gosmann,Melis N. Anahtar,Melis N. Anahtar,Scott A. Handley,Mara Farcasanu,Galeb Abu-Ali,Brittany A. Bowman,Nikita Padavattan,Chandni Desai,Lindsay Droit,Amber Moodley,Mary Dong,Yuezhou Chen,Nasreen Ismail,Thumbi Ndung'u,Musie Ghebremichael,Musie Ghebremichael,Duane R. Wesemann,Caroline M. Mitchell,Krista L. Dong,Curtis Huttenhower,Bruce D. Walker,Herbert W. Virgin,Douglas S. Kwon,Douglas S. Kwon +24 more
TL;DR: The results suggest that highly prevalent genital bacteria increase HIV risk by inducing mucosal HIV target cells, and specific taxa highly prevalent in young healthy South African women that increase their HIV risk might be leveraged to reduce HIV acquisition in women.
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Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike.
Pei Tong,Avneesh Gautam,Ian W. Windsor,Ian W. Windsor,Ian W. Windsor,Meghan Travers,Yuezhou Chen,Nicholas Garcia,Noah B. Whiteman,Lindsay G. A. McKay,Nadia Storm,Lauren E. Malsick,Anna N. Honko,Felipe J.N. Lelis,Shaghayegh Habibi,Simon Jenni,Yongfei Cai,Linda J. Rennick,W. Paul Duprex,Kevin R. McCarthy,Christy L. Lavine,Teng Zuo,Junrui Lin,Adam Zuiani,Jared Feldman,Elizabeth A. MacDonald,Blake M. Hauser,Anthony Griffths,Michael S. Seaman,Aaron G. Schmidt,Aaron G. Schmidt,Bing Chen,Donna Neuberg,Goran Bajic,Goran Bajic,Stephen C. Harrison,Duane R. Wesemann +36 more
TL;DR: The authors charted memory B cell receptor-encoded antibodies from 19 COVID-19 convalescent subjects against SARS-CoV-2 spike (S) and found seven major antibody competition groups against epitopes recurrently targeted across individuals.
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Immune recall improves antibody durability and breadth to SARS-CoV-2 variants
Yuezhou Chen,Pei Tong,Noah B. Whiteman,Ali Sanjari Moghaddam,Mehrdad Zarghami,Adam Zuiani,Shaghayegh Habibi,Avneesh Gautam,F. Keerti,Caihong Bi,Tianshu Xiao,Yongfei Cai,Bing Chen,Donna Neuberg,Duane R. Wesemann +14 more
TL;DR: It is concluded that SARS-CoV-2 antigen challenge histories in humans influence not only the speed and magnitude of antibody responses, but also functional cross-variant antibody repertoire composition and longevity.
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