Yuet Wai Kan
University of California, San Francisco
294 Papers
6.2K Citations
Yuet Wai Kan is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Gene & Globin. The author has an hindex of 88, co-authored 293 publications. Previous affiliations of Yuet Wai Kan include San Francisco General Hospital & Cardiovascular Institute Hospital.
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Papers
Organization of the ζ-α genes in Chinese
TL;DR: Analysis of α and ζ genes in 101 healthy normals and hospitalized patients with non‐haematological diseases revealed a 3% incidence of α thalassaemia in the local Chinese population of Hong Kong.
Organization of the alpha-globin genes in the Chinese alpha-thalassemia syndromes.
TL;DR: Using restriction endonuclease gene mapping, the organization of the alpha-globin genes in cellular DNA from Chinese subjects with various alpha-thalassemia syndromes is defined.
Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation
Yuet Wai Kan,Andrée M. Dozy +1 more
TL;DR: Restriction endonuclease mapping of the human globin genes revealed a genetic variation in a Hpa I recognition site about 5000 nucleotides from the 3' end of the beta-globin structural gene.
Efficient expression of CFTR function with adeno-associated virus vectors that carry shortened CFTR genes
Lei Zhang,Danher Wang,Horst Fischer,Peidong Fan,Jonathan Widdicombe,Yuet Wai Kan,Jian-yun Dong +6 more
TL;DR: This study engineered and tested 20 CFTR mini-genes containing deletions that were targeted to regions that may contain nonessential sequences and demonstrated that smaller AAV/CFTR vectors with a P5 promoter expressed the CFTR gene more efficiently than larger vectors or a vector in whichCFTR gene was expressed from the AAV inverted terminal repeat sequence.
Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization
TL;DR: Ch Chromosomal localization by fluorescence insitu hybridization demonstrates that these genes are nonsyntenic, and these three genes were probably derived from a single ancestor by chromosomal duplication as other genes that also map in these regions are related to one another.