16 Papers
54 Citations
Yuejin Wu is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Ca2+/calmodulin-dependent protein kinase & Voltage-dependent calcium channel. The author has an hindex of 9, co-authored 16 publications. Previous affiliations of Yuejin Wu include Vanderbilt University & Vanderbilt University Medical Center.
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Papers
Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels.
TL;DR: It is shown that the Ca2+/CaM-dependent protein kinase II (CaMK) is necessary and possibly sufficient for ICa facilitation, and CaMK-mediated phosphorylation is an essential signalling event in triggering Ca2-/Ca M-dependent ICafacilitation.
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RETRACTED: L-Type Ca2+ Channel Facilitation Mediated by Phosphorylation of the β Subunit by CaMKII
Chad E. Grueter,Sunday A. Abiria,Igor Dzhura,Yuejin Wu,Amy-Joan L. Ham,Peter J. Mohler,Mark E. Anderson,Roger J. Colbran +7 more
TL;DR: Findings reveal a molecular mechanism for targeting CaMKII to LTCCs and facilitating I(Ca) that may modulate Ca(2+) entry in diverse cell types coexpressing Ca MKII and the beta(2a) subunit.
193
Excessive O-GlcNAcylation Causes Heart Failure and Sudden Death.
Priya Umapathi,Olurotimi O. Mesubi,Partha S. Banerjee,Neha Abrol,Qinchuan Wang,Elizabeth D. Luczak,Yuejin Wu,Jonathan M. Granger,An-Chi Wei,Oscar E. Reyes Gaido,Liliana Florea,C. Conover Talbot,Gerald W. Hart,Natasha E. Zachara,Mark E. Anderson +14 more
TL;DR: In this paper, O-GlcNAcylation (the attachment of O-linked β-N-... ) was used to identify heart failure as a leading cause of death worldwide and is associated with the rising prevalence of obesity, hypertension, and diabetes.
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Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms.
Olurotimi O. Mesubi,Adam G. Rokita,Neha Abrol,Yuejin Wu,Biyi Chen,Qinchuan Wang,Jonathan M. Granger,Anthony Tucker-Bartley,Elizabeth D. Luczak,Kevin R. Murphy,Priya Umapathi,Partha S. Banerjee,Tatiana Boronina,Robert N. Cole,Lars S. Maier,Xander H.T. Wehrens,Joel L. Pomerantz,Long-Sheng Song,Rexford S. Ahima,Gerald W. Hart,Natasha E. Zachara,Mark E. Anderson +21 more
TL;DR: It is shown that T1D and T2D significantly increased AF, and this increase required CaMKII and OGN, and it is suggested ROS primarily promotes AF by ox-CaMKII, while OGN promotesAF by a CaMK II-independent mechanism(s).
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Reduced repolarization reserve in ventricular myocytes from female mice
TL;DR: Ventricular action potential repolarization is prolonged in myocytes from female compared to male mice and female mice have reduced RR that is unmasked by FK506, suggesting that gender is an important variable for cardiovascular studies using mice.
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