Yue Wu
Nantong University
11 Papers
24 Citations
Yue Wu is an academic researcher from Nantong University. The author has contributed to research in topics: Neuroinflammation & Tail suspension test. The author has an hindex of 6, co-authored 10 publications.
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Papers
The ketone body metabolite β-hydroxybutyrate induces an antidepression-associated ramification of microglia via HDACs inhibition-triggered Akt-small RhoGTPase activation
Chao Huang,Peng Wang,Xing Xu,Yaru Zhang,Yu Gong,Wenfeng Hu,Minhui Gao,Yue Wu,Yong Ling,Xi Zhao,Yibin Qin,Rongrong Yang,Wei Zhang +12 more
TL;DR: It is reported that BHB as well as its producing stimuli fasting and KD induced obvious ramifications of murine microglia in basal and inflammatory conditions in a reversible manner, and these ramifications were accompanied with microglial profile toward M2 polarization and phagocytosis.
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Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition
Peng Wang,Yaru Zhang,Yu Gong,Rongrong Yang,Zhuo Chen,Wenfeng Hu,Yue Wu,Minhui Gao,Xing Xu,Yibin Qin,Chao Huang +10 more
TL;DR: Results showed that SB induced reversible elongations of microglial process in both normal and inflammatory conditions, and these elongations were accompanied with significant changes in markers reflecting the pro-inflammatory and anti-inflammatory status of microGlia.
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Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation.
Yu Gong,Lijuan Tong,Rongrong Yang,Wenfeng Hu,Xingguo Xu,Wang Wenjing,Peng Wang,Xu Lu,Minhui Gao,Yue Wu,Xing Xu,Yaru Zhang,Zhuo Chen,Chao Huang +13 more
TL;DR: Results reveal an etiological role of hippocampal microglia loss in ESI‐induced depression and demonstrate that the restoration of microglial homeostasis in the hippocampus may serve as a therapeutic strategy for depression induced by early‐life stress.
74
Tauroursodeoxycholic acid produces antidepressant-like effects in a chronic unpredictable stress model of depression via attenuation of neuroinflammation, oxido-nitrosative stress, and endoplasmic reticulum stress.
TL;DR: Results revealed that TUDCA improved the CUS‐induced depression‐like behaviors likely through attenuation of neuroinflammation, oxido‐nitrosative, and ER stress.
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Identification of a microglial activation-dependent antidepressant effect of amphotericin B liposome.
Minhui Gao,Peili Hu,Zixuan Cai,Yue Wu,Dan Wang,Wenfeng Hu,Xing Xu,Yaru Zhang,Xu Lu,Dongjian Chen,Zhuo Chen,Kai Ma,Jie Wen,Hui Wang,Chao Huang +14 more
TL;DR: Results not only identify a novel pharmacological effect of amphotericin B liposome, but further support the notion that microglial activation in the hippocampus is a potential strategy for depression therapy.
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