Yuan Gao
Johns Hopkins University
73 Papers
288 Citations
Yuan Gao is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: DNA methylation & Gene. The author has an hindex of 34, co-authored 61 publications. Previous affiliations of Yuan Gao include University of Memphis & IBM.
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Papers
Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates
Gregory Hannum,Justin Guinney,Ling Zhao,Ling Zhao,Li Zhang,Guy Hughes,Srinivas R. Sadda,Brandy Klotzle,Marina Bibikova,Jian-Bing Fan,Yuan Gao,Rob Deconde,Menzies Chen,Indika Rajapakse,Stephen H. Friend,Trey Ideker,Kang Zhang,Kang Zhang +17 more
TL;DR: A quantitative model of aging is built using measurements at more than 450,000 CpG markers from the whole blood of 656 human individuals, aged 19 to 101, to measure the rate at which an individual's methylome ages, which is impacted by gender and genetic variants.
3.5K
Next-Generation Digital Information Storage in DNA
TL;DR: This work developed a strategy to encode arbitrary digital information in DNA, wrote a 5.27-megabit book using DNA microchips, and read the book by using next-generation DNA sequencing.
1.4K
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells.
Madeleine Ball,Jin Billy Li,Yuan Gao,Je-Hyuk Lee,Emily M LeProust,In-Hyun Park,Bin Xie,George Q. Daley,George M. Church +8 more
TL;DR: Two complementary approaches that use next-generation sequencing technology to detect cytosine methylation are introduced and it is confirmed that gene-body methylation in highly expressed genes is a consistent phenomenon throughout the human genome.
Neuronal activity modifies the DNA methylation landscape in the adult brain
Junjie U. Guo,Dengke K. Ma,Huan Mo,Madeleine Ball,Mi Hyeon Jang,Michael A. Bonaguidi,Jacob A. Balazer,Hugh L. Eaves,Bin Xie,Eric C. Ford,Kun Zhang,Guo Li Ming,Yuan Gao,Hongjun Song +13 more
TL;DR: This study quantitatively compared the CpG methylation landscape of adult mouse dentate granule neurons in vivo before and after synchronous neuronal activation, and implicates modification of the neuronal DNA methylome as a previously underappreciated mechanism for activity-dependent epigenetic regulation in the adult nervous system.
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Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming
Jie Deng,Robert Shoemaker,Bin Xie,Athurva Gore,Emily M LeProust,Jessica Antosiewicz-Bourget,Dieter Egli,Nimet Maherali,In-Hyun Park,Junying Yu,George Q. Daley,Kevin Eggan,Konrad Hochedlinger,James A. Thomson,Wei Li Wang,Yuan Gao,Kun Zhang +16 more
TL;DR: A method to specifically capture an arbitrary subset of genomic targets for single-molecule bisulfite sequencing for digital quantification of DNA methylation at single-nucleotide resolution is reported.
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