Yu Yan
Peking University
6 Papers
Yu Yan is an academic researcher from Peking University. The author has contributed to research in topics: Adipocyte & Adipose tissue. The author has an hindex of 3, co-authored 6 publications.
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Papers
Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism.
X P Zhang,Yangming Zhang,Pengcheng Wang,Song-Yang Zhang,Yongqiang Dong,Guangyi Zeng,Yu Yan,Lulu Sun,Qing Wu,Huiying Liu,Bo Liu,Wei Kong,Xian Wang,Changtao Jiang +13 more
TL;DR: Adipose overexpression of ACER2 rescued adipocyte HIF-2α-deficiency-induced exacerbation of atherosclerosis and activated the HIF prolyl hydroxylase inhibitor FG-4592, which had protective effects on Atherosclerosis.
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Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis
Qing Wu,Lulu Sun,Xiaomin Hu,Xuemei Wang,Feng Xu,Bo Chen,Xianyi Liang,Jialin Xia,Pengcheng Wang,Daisuke Aibara,Shaofei Zhang,Guangyi Zeng,Chuyu Yun,Yu Yan,Yicheng Zhu,Michael Bustin,Shuyang Zhang,Frank J. Gonzalez,Changtao Jiang +18 more
TL;DR: In this article, the role of intestinal FXR in atherosclerosis and its potential as a target for clinical treatment have not been explored, but it is known that the serum levels of fibroblast growth factor 19 (FGF19), encoded by an FXR target gene, were much higher in patients with hypercholesterolemia than in control subjects and were positively related to circulating ceramide levels.
Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance.
Xiaopeng Li,Xiujuan Zhang,Xiujuan Zhang,Jialin Xia,Linqi Zhang,Bo Chen,Guan Lian,Chuyu Yun,Juan Yang,Yu Yan,Pengcheng Wang,Xuemei Wang,Bo Liu,Huiying Liu,Hui Liang,Yanli Pang,Xian Wang,Changtao Jiang +17 more
TL;DR: This article showed that deficiency of HIF-2α in macrophages results in excessive activation of the NLRP3 inflammasome in a manner dependent on CPT1A-mediated enhancement of fatty acid oxidation (FAO).
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Disruption of adipocyte HIF-1α improves atherosclerosis through the inhibition of ceramide generation
Pengcheng Wang,Guangyi Zeng,Yu Yan,Song-Yang Zhang,Yongqiang Dong,Yangming Zhang,X P Zhang,Huiying Liu,Zhipeng Zhang,Changtao Jiang,Yanli Pang +10 more
TL;DR: In high cholesterol diet-fed ApoE–/– mice, adipocyte Hif-1α deficiency or direct HIF-1 α inhibition by the selective pharmacological HIF -1α inhibitor PX-478 alleviates higholesterol diet-induced atherosclerosis by reducing adipose ceramide generation, which lowers cholesterol levels and reduces inflammatory responses, resulting in improved dyslipidemia and atherogenesis.
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Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner.
Yu Yan,Xun Wu,Pengcheng Wang,Song-Yang Zhang,Lulu Sun,Yang Zhao,Guangyi Zeng,Bo Liu,Guoheng Xu,Huiying Liu,Lei Wang,Xian Wang,Changtao Jiang +12 more
TL;DR: It is revealed that Hcy activates adipocyte lipolysis and the potential utility of targeted ER redox homeostasis for treating Hcy-induced NAFL is suggested.
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