5 Papers
28 Citations
Yu Xia is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Gene delivery & Micelle. The author has an hindex of 5, co-authored 5 publications.
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Papers
The fine-tuning of thermosensitive and degradable polymer micelles for enhancing intracellular uptake and drug release in tumors.
Wei Li,Jinfeng Li,Jie Gao,Bohua Li,Yu Xia,Yanchun Meng,Yongsheng Yu,Huaiwen Chen,Jianxin Dai,Hao Wang,Yajun Guo +10 more
TL;DR: The finely tailored dual functional core-shell micelles are potent in enhancing cellular uptake and drug release and in vitro cytotoxicity assay against N-87 cancer cell and confocal laser scanning microscopy also confirmed such promoting efficiency.
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The promotion of siRNA delivery to breast cancer overexpressing epidermal growth factor receptor through anti-EGFR antibody conjugation by immunoliposomes
Jie Gao,Wei Liu,Yu Xia,Wei Li,Jing Sun,Huaiwen Chen,Bohua Li,Dapeng Zhang,Weizhu Qian,Yanchun Meng,Li Deng,Hao Wang,Jianming Chen,Yajun Guo +13 more
TL;DR: In this article, a self-assembling process followed by an anti-EGFR antibody conjugation was performed to obtain optimized TLPD conjugated with antiEGFR Fab' by conventional conjugations, which possessed a small size around 150nm and superior in vitro stability.
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Polymer–lipid hybrid nanoparticles conjugated with anti-EGF receptor antibody for targeted drug delivery to hepatocellular carcinoma
Jie Gao,Yu Xia,Huaiwen Chen,Yongsheng Yu,Jinjing Song,Wei Li,Weizhu Qian,Hao Wang,Jianxin Dai,Yajun Guo +9 more
TL;DR: In this article, the authors obtained adriamycin-loaded polymer-lipid hybrid nanoparticles conjugated with anti-EGF receptor antibody (PLNP-Mal-EGFR) for hepatocellular carcinoma (HCC) chemotherapy.
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Self-assembled supramolecular nano vesicles for safe and highly efficient gene delivery to solid tumors
Wei Li,Huafei Li,Jinfeng Li,Huajing Wang,He Zhao,Li Zhang,Yu Xia,Zengwei Ye,Jie Gao,Jianxin Dai,Hao Wang,Yajun Guo +11 more
TL;DR: This study successfully circumvented the traditional dilemma of efficient gene transfection at a high nitrogen- from-polyethylenimine to phosphate-from-DNA ratio that is accompanied with site cytotoxicity and low stability and shows significant potential for use in practical gene therapy.
A nanogel with passive targeting function and adjustable polyplex surface properties for efficient anti-tumor gene therapy
Haizhou Zhang,Qingbao Li,Yingying Zhang,Yu Xia,Liang Yun,Qian Zhang,Tao Zhang,Xia Chen,Huaiwen Chen,Wei Li +9 more
TL;DR: Through modifying the “gold-standard” transfection agent poly(ethylenimine) with non-cytotoxic monomer N-isopropylacrylamide (NIPAM), a thermosensitive cationic PNIPam/PEI nanogel is developed which significantly suppressed tumor growth and indicated its high potent for practical gene therapy.
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