Yu-Sheng Yeh
Kyoto University
15 Papers
12 Citations
Yu-Sheng Yeh is an academic researcher from Kyoto University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 4 publications.
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Papers
Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 level in mice.
Tomoya Sakamoto,Takahiro Nitta,Koji Maruno,Yu-Sheng Yeh,Hidetoshi Kuwata,Koichi Tomita,Tsuyoshi Goto,Nobuyuki Takahashi,Teruo Kawada +8 more
TL;DR: It is suggested that inflammation induced by infiltrated M1 Mϕ could cause not only insulin resistance but also reduction of energy expenditure in adipose tissues.
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α-Linolenic acid-derived metabolites from gut lactic acid bacteria induce differentiation of anti-inflammatory M2 macrophages through G protein-coupled receptor 40.
Ryuji Ohue-Kitano,Yumiko Yasuoka,Tsuyoshi Goto,Nahoko Kitamura,Si-Bum Park,Shigenobu Kishino,Ikuo Kimura,Mayu Kasubuchi,Haruya Takahashi,Yongjia Li,Yu-Sheng Yeh,Huei-Fen Jheng,Mari Iwase,Masashi Tanaka,Shinya Masuda,Takayuki Inoue,Hajime Yamakage,Toru Kusakabe,Fumito Tani,Akira Shimatsu,Nobuyuki Takahashi,Jun Ogawa,Noriko Satoh-Asahara,Teruo Kawada +23 more
TL;DR: A novel mechanism of M2 macrophage differentiation involving fatty acids from gut lactic acid bacteria and GPCR40 signaling is suggested.
83
Use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in atherosclerosis
Xiangyu Zhang,Santosh K. Misra,Parikshit Moitra,Xiuli Zhang,Se Jin Jeong,Jeremiah Stitham,Astrid Rodriguez-Velez,Arick C. Park,Yu-Sheng Yeh,William E. Gillanders,Daping Fan,Abhinav Diwan,Jaehyung Cho,Slava Epelman,Irfan J. Lodhi,Dipanjan Pan,Babak Razani +16 more
TL;DR: The use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in the treatment of atherosclerosis is supported, with results in cultured macrophages indicating that the PLGA-based nanoparticles are the most effective at trafficking to and enhancing acidification of lysOSomes.
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Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk
Xiangyu Zhang,Divya S. Kapoor,Se-Jin Jeong,A. Fappi,Jeremiah Stitham,Vasavi Shabrish,Ismail Sergin,Eman Yousif,Astrid Rodriguez-Velez,Yu-Sheng Yeh,Arick C. Park,Arif Yurdagul,Oren Rom,Slava Epelman,Joel D. Schilling,Marco Sardiello,Abhinav Diwan,Jaehyung Cho,Nathan O. Stitziel,Ali Javaheri,Irfan J. Lodhi,Bettina Mittendorfer,Babak Razani +22 more
TL;DR: Zhang et al. use human studies and mechanistic work in mouse models to describe how leucine serves as the key amino acid derived from dietary protein to drive deleterious macrophage mTORC1 signalling and promote cardiovascular disease.
16
Geranylgeranyl pyrophosphate performs as an endogenous regulator of adipocyte function via suppressing the LXR pathway
Yu-Sheng Yeh,Tsuyoshi Goto,Nobuyuki Takahashi,Kahori Egawa,Haruya Takahashi,Huei-Fen Jheng,Young-Il Kim,Teruo Kawada +7 more
TL;DR: It is shown that GGPP inhibits adipocytes differentiation via the liver X receptors (LXRs) pathway and Ggps knockdown up-regulates LXR target genes during adipocyte differentiation, suggesting thatGGPP may act as an endogenous regulator of adipocyte differentiate and maturation through a mechanism partially dependent on the LXR pathway.
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