18 Papers
119 Citations
Yu Sha is an academic researcher from Shenyang Pharmaceutical University. The author has contributed to research in topics: Ring (chemistry) & Docking (molecular). The author has an hindex of 7, co-authored 18 publications.
Chat about Author
Papers
Facile synthesis of oleanolic acid monoglycosides and diglycosides.
TL;DR: This method is suitable for preparing oleanolic acid glycosides with structural diversity for extensive biological evaluation and structure-activity relationship study, and it also apply new idea for the corresponding synthetic methods to the glycoside derivatives of other triterpenoid.
Facile synthesis and cytotoxicity of triterpenoid saponins bearing a unique disaccharide moiety: hederacolchiside A1 and its analogues
TL;DR: An improved synthetic approach toward hederacolchiside A1, an antitumor triterpenoid saponin bearing a unique disaccharide moiety, was established from a partially protected intermediate and avoided tedious protection-deprotection manipulation.
24
Assignment of the absolute configuration of (-)-linarinic acid by theoretical calculation and asymmetric total synthesis
Maosheng Cheng,Qiang Li,Bin Lin,Yu Sha,Jinhong Ren,Yan He,Qinghe Wang,Hui-Ming Hua,Kenneth Ruud +8 more
TL;DR: In this paper, the specific rotation of (−)-linarinic acid calculated using Hartree-Fock and density functional theory on 14 representative conformers of this molecule were all negative, and an asymmetric total synthesis with starting products chosen on the basis of the theoretical calculations was found to corroborate the theoretical assignment.
20
Structure prediction and R115866 binding study of human CYP26A1: homology modelling, fold recognition, molecular docking and MD simulations
Jinhong Ren,Xu-Qiong Xiong,Yu Sha,Maocai Yan,B. Lin,Jian Wang,Yongkui Jing,Dongmei Zhao,Maosheng Cheng +8 more
TL;DR: This constructed CYP26A1 model may provide an opportunity to understand the action mode of the enzyme and could be useful in designing novel retinoic acid metabolism blocking agents (RAMBAs).
14
Chalcone derivatives inhibit glutathione S-transferase P1-1 activity: insights into the interaction mode of alpha, beta-unsaturated carbonyl compounds.
Jian Wang,Shao-Jie Wang,Dan-Dan Song,Dongmei Zhao,Yu Sha,Yuting Jiang,Yongkui Jing,Maosheng Cheng +7 more
TL;DR: Molecular field‐based similarity analysis provides the necessary three‐dimensional molecular field properties of α, β‐unsaturated carbonyl derivatives to inhibit glutathione S‐transferase P1‐1 activity, which has great potential to be developed into novel chemotherapeutic sensitizers.
13