Yu-Ru Ma
Shanghai Jiao Tong University
12 Papers
15 Citations
Yu-Ru Ma is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Single-nucleotide polymorphism & Genome-wide association study. The author has an hindex of 6, co-authored 12 publications.
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Papers
The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes.
Feng Sun,Jun-Xiu Zhang,Chang-Yi Yang,Guan-Qi Gao,Wen-Bin Zhu,Bing Han,Lele Zhang,Yue-Yue Wan,Xiao-Ping Ye,Yu-Ru Ma,Man-Man Zhang,Liu Yang,Qian-Yue Zhang,Wei Liu,Cui-Cui Guo,gang Chen,Shuang-Xia Zhao,Ke-Yi Song,Huai-Dong Song +18 more
TL;DR: Most cases of congenital hypothyroidism in China were caused by thyroid dyshormonogenesis rather than thyroid dysgenesis, and DUOX2 was the most frequently mutated gene in these patients, which was significantly different from Western countries.
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Genetic Study in a Large Cohort Supported Different Pathogenesis of Graves' Disease and Hashimoto's Hypothyroidism.
Qian-Yue Zhang,Wei Liu,Lu Li,Wen-Hua Du,Chun-Lin Zuo,Xiao-Ping Ye,Zheng Zhou,Fei-Fei Yuan,Yu-Ru Ma,Feng Sun,Sha-Sha Yu,Hui-Jun Xie,Chang-Run Zhang,Ying-Xia Ying,Guoyue Yuan,Guan-Qi Gao,Jun Liang,Shuang-Xia Zhao,Huai-Dong Song +18 more
TL;DR: The findings suggested that the pathogenesis of HT and GD was different, with six susceptibility loci with heterogeneity between GD and HT and four loci associated with GD, but not with HT including HLA-DPB1, CD40, TSHR and TG.
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Assessment of Molecular Subtypes in Thyrotoxic Periodic Paralysis and Graves Disease Among Chinese Han Adults: A Population-Based Genome-Wide Association Study.
Shuang-Xia Zhao,Wei Liu,Jun Liang,Guan-Qi Gao,Xiao-Mei Zhang,Yu Yao,Hai-Ning Wang,Fei-Fei Yuan,Li-Qiong Xue,Yu-Ru Ma,Lele Zhang,Xiao-Ping Ye,Qian-Yue Zhang,Feng Sun,Rui-Jia Zhang,Shao-Ying Yang,Ming Zhan,Wen-Hua Du,Bing-Li Liu,Xia Chen,Zhi-Yi Song,Xue-Song Li,Ping Li,Ying Ru,Chun-Lin Zuo,Sheng-Xian Li,Bing Han,Hui Zhu,Jie Qiao,Miao Xuan,Bin Su,Fei Sun,Jun-Hua Ma,Jia-Lun Chen,Haoming Tian,Sai-Juan Chen,Huai-Dong Song +36 more
- 03 May 2019
TL;DR: A complete genetic architecture will be helpful to understand the pathophysiology of TPP, and a useful prediction model could prevent the onset ofTPP, suggesting TPP as a molecular subtype of Graves disease.
ITM2A Expands Evidence for Genetic and Environmental Interaction in Graves Disease Pathogenesis
Xiao-Ping Ye,Fei-Fei Yuan,Lele Zhang,Yu-Ru Ma,Man-Man Zhang,Wei Liu,Feng Sun,Jing Wu,Meng Lu,Li-Qiong Xue,Jing-Yi Shi,Shuang-Xia Zhao,Huai-Dong Song,Jun Liang,Cui-Xia Zheng +14 more
TL;DR: It is suggested that ITM2A might be a susceptibility gene for GD in the Xq21.1 locus, and environmental factors probably contribute to GD pathogenesis by interacting with the risk SNP rs3827440 mediating the regulation of ITM 2A expression.
A dense mapping study of six European AITD susceptibility regions in a large Chinese Han Cohort of Graves' disease.
Wei Liu,Qian-Yue Zhang,Fei-Fei Yuan,Hai-Ning Wang,Lele Zhang,Yu-Ru Ma,Xiao-Ping Ye,Man-Man Zhang,Zhi-Yi Song,Sheng-Xian Li,Wen-Hua Du,Jun Liang,Xiao-Mei Zhang,Guan-Qi Gao,Shuang-Xia Zhao,Fengling Chen,Huai-Dong Song +16 more
TL;DR: The six susceptibility loci of GD identified from European population in Chinese Han population are investigated and the genetic heterogeneity of them in stratification of GD patients is estimated.
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