Yu-Qing Du
Peking University
6 Papers
4 Citations
Yu-Qing Du is an academic researcher from Peking University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications.
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Papers
Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates
Yu-Qing Du,Zhen Liang,Sheng Wang,Dong Sun,Xiaofeng Wang,Soon Yi Liew,Shuaiyao Lu,Shuangshuang Wu,Yong Jiang,Yaqi Wang,Boya Zhang,Wenhai Yu,Zhiying Lu,Yue Pu,Yun-Jin Zhang,Haiting Long,Shanshan Xiao,Rui Liang,Zhengyuan Zhang,Jingyang Guan,Jinlin Wang,Huixia Ren,Yanling Wei,Jiaxu Zhao,Shicheng Sun,Tengli Liu,Gaofan Meng,Lei Wang,Jiabin Gu,Tao Wang,Yinan Liu,Cheng Li,Chao Tang,Zhong-yang Shen,Xiaozhong Peng,Hongkui Deng +35 more
TL;DR: This study generated islets from human chemically induced pluripotent stem cells (hCiPSC-islets) and shows that a one-dose intraportal infusion into diabetic non-human primates effectively restored endogenous insulin secretion and improved glycemic control.
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Effect of Yinqi ointment on wound morphology and growth factor in treating diabetic foot ulcer
TL;DR: Yinqi ointment can promote the healing of DFU, and its mechanism may be related to the increase of the content of growth factor in granulation tissue.
3
Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells.
Huijuan Hua,Yaqi Wang,Xiaofeng Wang,Shusen Wang,Yunlu Zhou,Yinan Liu,Zhen Liang,Huixia Ren,Sufang Lu,Shuangshuang Wu,Yong Jiang,Yue Pu,Xiang Zheng,Chao Tang,Zhongyang Shen,Cheng Li,Yu-Qing Du,Hongkui Deng +17 more
TL;DR: Remodeling ceramide homeostasis in human pluripotent stem cell-derived β cells promotes functional maturation through metabolic adaptation, removal of negative regulators, and establishment of a specialized transcriptome and epigenome, enhancing insulin processing and glucose-stimulated insulin secretion.
3
Chemical reprogramming of melanocytes to skeletal muscle cells
Wenjun Yang,Yaqi Wang,Yu-Qing Du,Jiyong Li,Minzhi Jia,Sheng Li,Ruimiao Ma,Cheng Li,Hongkui Deng,Ping Hu +9 more
TL;DR: In this article , a set of master transcription factors (TFs) of the target cell type was reactivated using only small molecules, which has proven to be difficult to use for direct cell-fate conversion.
3
Implantation underneath the abdominal anterior rectus sheath enables effective and functional engraftment of stem-cell-derived islets
Zhen Liang,Dong Sun,Shuaiyao Lu,Zhengjun Lei,Sheng Wang,Zhifeng Luo,Jinqin Zhan,Shuangshuang Wu,Yong Jiang,Zhi Lu,Shicheng Sun,Yingying Shi,Haiting Long,Yanling Wei,Wenhai Yu,Zhihui Wang,Liew Soon Yi,Yun-Peng Zhang,Wenyong Sun,Xiaofeng Fang,Yanyan Li,Sufang Lu,Jiayun Lv,Wei-Guo Sui,Zhong-yang Shen,Xiaozhong Peng,Yu-Qing Du,Hongkui Deng +27 more
TL;DR: It is found that hPSC islets survive and gradually mature after transplantation, leading to improved glycemic control in diabetic primates, and a new transplantation site in the abdomen, the subanterior rectus sheath, is shown to allow for functional maturation of stem-cell-derived islet cells and improved gly glucose control in nonhuman primates.