10 Papers
19 Citations
Yu Lu is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Chemistry & Mesenchymal stem cell. The author has an hindex of 3, co-authored 5 publications.
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Papers
Bone regeneration is mediated by macrophage extracellular vesicles.
Miya Kang,Chun-Chieh Huang,Yu Lu,Sajjad Shirazi,Praveen Gajendrareddy,Sriram Ravindran,Lyndon F. Cooper +6 more
TL;DR: Functional studies implicate polarized macrophage EV miRNAs in the positive or negative regulation of bone bone regeneration that was observed in vivo and indicate that macrophages polarization influences EV cargo and related EV function in the paracrineregulation of bone regeneration.
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Functionally engineered extracellular vesicles improve bone regeneration.
Chun-Chieh Huang,Miya Kang,Yu Lu,Sajjad Shirazi,Jose Iriarte Diaz,Lyndon F. Cooper,Praveen Gajendrareddy,Sriram Ravindran +7 more
TL;DR: EV' functionality may be engineered by genetic modification of the parental MSCs to induce osteoinduction and bone regeneration, indicating alternative approaches to enhancing bone regeneration.
133
3D Encapsulation and tethering of functionally engineered extracellular vesicles to hydrogels
Chun-Chieh Huang,Miya Kang,Sajjad Shirazi,Yu Lu,Lyndon F. Cooper,Praveen Gajendrareddy,Sriram Ravindran +6 more
TL;DR: In this article, the authors used osteoinductive functionally engineered extracellular vesicles (FEEs) derived from mesenchymal stem cell (MSC) derived EVs to provide a tunable platform for EV delivery that can be formulated as an injectable material or a bulk hydrogel suitable for regenerative medicine applications.
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Extracellular Vesicles From TNFα Preconditioned MSCs: Effects on Immunomodulation and Bone Regeneration
Miya Kang,Chun Chieh Huang,Praveen Gajendrareddy,Yu Lu,Sajjad Shirazi,Sriram Ravindran,Lyndon F. Cooper +6 more
TL;DR: The results indicate that MSC exposure to inflammatory signals influence the MSC EV’s immunomodulatory function in the context of tissue repair, and the TNFα preconditioned MSC EVs possess enhanced immunommodulatory properties.
37
The importance of cellular and exosomal miRNAs in mesenchymal stem cell osteoblastic differentiation
TL;DR: In this article, the importance of MSC miRNAs in modulation of osteoblastic differentiation was examined by global reduction of miRNA biosynthesis in Dicer knock down hMSCs.