Yu Liu
Rutgers University
15 Papers
37 Citations
Yu Liu is an academic researcher from Rutgers University. The author has contributed to research in topics: Connexin & RNA polymerase. The author has an hindex of 6, co-authored 15 publications. Previous affiliations of Yu Liu include University of Medicine and Dentistry of New Jersey.
Chat about Author
Papers
Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.
Wei Lin,Soma Mandal,David Degen,Yu Liu,Yon W. Ebright,Shengjian Li,Yu Feng,Yunpeng Zhang,Sukhendu Mandal,Yilin Jiang,Shuang Liu,Matthew Gigliotti,Meliza Talaue,Nancy D. Connell,Kalyan Das,Eddy Arnold,Richard H. Ebright +16 more
TL;DR: The results identify an Mtb-specific structural module of Mtb RNAP and establish that Rif functions by a steric-occlusion mechanism that prevents extension of RNA.
151
Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3)
Wei Lin,Kalyan Das,David Degen,Abhishek Mazumder,Diego Duchi,Dongye Wang,Yon W. Ebright,Richard Y. Ebright,Elena V. Sineva,Matthew Gigliotti,Aashish Srivastava,Sukhendu Mandal,Yi Jiang,Yu Liu,Ruiheng Yin,Zhening Zhang,Edward T. Eng,Dennis Thomas,Stefano Donadio,Haibo Zhang,Changsheng Zhang,Achillefs N. Kapanidis,Richard H. Ebright +22 more
TL;DR: A cryo-EM structure of Mycobacterium tuberculosis RNAP holoenzyme in complex with Lpm at 3.5-Å resolution shows that Lpm binds at the base of the RNAP "clamp."
104
Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition
Wei Lin,Soma Mandal,David Degen,Yu Liu,Yon W. Ebright,Shengjian Li,Yu Feng,Yu Zhang,Sukhendu Mandal,Yi Jiang,Shuang Liu,Matthew Gigliotti,Meliza Talaue,Nancy D. Connell,Kalyan Das,Eddy Arnold,Richard H. Ebright +16 more
TL;DR: Structures of Mycobacterium tuberculosis RNA polymerase reveal taxon-specific properties and binding sites of known and new antituberculosis agents and establish that Rif functions by a steric-occlusion mechanism that prevents extension of RNA.
36
Divalent regulation and intersubunit interactions of human connexin26 (Cx26) hemichannels.
TL;DR: It is found that the D 50-Q48 interaction contributes to stabilization of the open state, but that it is relatively insensitive to disruption by extracellular Ca2+ compared with the D50-K61 interaction.
24
Polydisperse molecular architecture of connexin 26/30 heteromeric hemichannels revealed by atomic force microscopy imaging.
Pamela A. Naulin,Benjamin Lozano,Christian Fuentes,Yu Liu,Carla Schmidt,Jorge E. Contreras,Nelson P. Barrera +6 more
TL;DR: To the knowledge, this is the first time that the molecular architecture of heteromeric Cx channels has been revealed, thus providing the basis to explore the functional effect of these channels in biology.
6