17 Papers
81 Citations
Yu Li is an academic researcher from Chongqing Medical University. The author has contributed to research in topics: Curcumin & Liver X receptor. The author has an hindex of 9, co-authored 16 publications.
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Papers
Curcumin activates Wnt/β-catenin signaling pathway through inhibiting the activity of GSK-3β in APPswe transfected SY5Y cells.
TL;DR: Curcumin could activate the Wnt/β-catenin signaling pathway through inhibiting theexpression of GSK-3β and inducing the expression of β-catanin and CyclinD1, which will provide a new theory for treatment of neurodegenerative diseases by Curcumin.
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Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer’s Disease and Systemic Inflammation
TL;DR: It is concluded that an imbalance of TLR4/TREM2 may be a potential link between AD and systemic inflammation and can serve as a potential therapeutic target for treating systemic inflammation in AD progression.
104
DNA Demethylation Upregulated Nrf2 Expression in Alzheimer’s Disease Cellular Model
Huimin Cao,Li Wang,Beibei Chen,Peng Zheng,Yi He,Yubin Ding,Yushuang Deng,Xi Lu,Xiuming Guo,Yuping Zhang,Yu Li,Gang Yu +11 more
TL;DR: DNA demethylation promoted the Nrf2 cell signaling pathway, which may enhance the antioxidant system against AD development, and was concomitant with increased nuclear translocation of NRF2 and higher expression of NAD(P)H:quinone oxidoreductas (NQO1).
Curcumin Induces ABCA1 Expression and Apolipoprotein A-I-Mediated Cholesterol Transmembrane in the Chronic Cerebral Hypoperfusion Aging Rats
TL;DR: It is concluded that curcumin has the ability to activate permissive LXR-β/RXR-α signaling and thereby modulate ABCA1 and apoA-I-mediated cholesterol transmembrane transportation, which is a new preventive and therapeutic strategy for cerevascular diseases.
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Overexpression of MAP-2 via Formation of Microtubules Plays an Important Role in the Sprouting of Mossy Fibers in Epileptic Rats
TL;DR: Overexpression of MAP-2 via formation of microtubules plays an important role in the sprouting of mossy fibers in epileptic rats.
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