6 Papers
Yu Li is an academic researcher from Hunan Normal University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 2, co-authored 4 publications.
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Papers
Recent ring distortion reactions for diversifying complex natural products.
TL;DR: This work reviews the ring distortion reactions recently used in complexity-to-diversity (CtD) and pseudo natural products (pseudo-NPs) strategies for diversifying complex natural products and provides a toolbox for chemists for the application of ring distort reactions to access natural product-like molecules.
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Biatractylolide Modulates PI3K-Akt-GSK3β-Dependent Pathways to Protect against Glutamate-Induced Cell Damage in PC12 and SH-SY5Y Cells.
TL;DR: Findings indicate that biatractylolide has a neuroprotective effect on glutamate-induced injury in PC12 and SH-SY5Y cells through a mechanism of the PI3K-Akt-GSK3β-dependent pathways.
Patent
Cholesterol hydrophobic modification pullulan-donepezil-polysorbate 80 nano particle as well as preparation and application
Tao Xiaojun,Feng Xing,Xiaoping Yang,Li Zhu,Yu Li,Hu Qian +5 more
- 10 Aug 2018
TL;DR: In this paper, a cholesterol hydrophobic modification pullulan-donepezil-polysorbate 80 nano particle has been used for maintaining blood concentration within a longer time, prolonging medicine taking intervals and improving patient compliance.
Preparation and Drug Release Study of Novel Nanopharmaceuticals with Polysorbate 80 Surface Adsorption
TL;DR: Compared to DZP-CHP alone, PS-DZP -CHP can enhance the release of donepezil and improve the water solubility ofdonepezil while enhancing its targeting and sustained release.
Brain-Targeted Polysorbate 80-Emulsified Donepezil Drug-Loaded Nanoparticles for Neuroprotection.
Xiaojun Tao,Siyu Mao,Qiufang Zhang,Hongyuan Yu,Yu Li,Xiangling He,Shanyi Yang,Zhirong Zhang,Ziqi Yi,Yujiao Song,Xing Feng +10 more
TL;DR: Wang et al. as mentioned in this paper designed a new nanopreparation (PS-DZP-CHP): cholesterol-modified pullulan (CHP) nanoparticle with polysorbate 80(PS) surface coverage, as donepezil (DZp) carrier to realize brain tissue delivery.