The transient receptor potential vanilloid 2 (TRPV2) channel is a nonselective cation channel that has been implicated in multiple sensory processes in the nervous system. Here, it is shown that TRPV2 in myeloid cells facilitates virus penetration by promoting the tension and mobility of cell membrane through the Ca2+‐LRMDA axis. Knockout of TRPV2 in myeloid cells or inhibition of TRPV2 channel activity suppresses viral infection and protects mice from herpes simplex virus 1 (HSV‐1) and vesicular stomatitis virus (VSV) infection. Reconstitution of TRPV2 but not the Ca2+‐impermeable mutant TRPV2E572Q into LyZ2‐Cre;Trpv2fl/fl bone marrow‐derived dendritic cells (BMDCs) restores viral infection. Mechanistically, knockout of TRPV2 in myeloid cells inhibits the tension and mobility of cell membrane and the penetration of viruses, which is restored by reconstitution of TRPV2 but not TRPV2E572Q. In addition, knockout of TRPV2 leads to downregulation of Lrmda in BMDCs and BMDMs, and knockdown of Lrmda significantly downregulates the mobility and tension of cell membrane and inhibits viral infections in Trpv2fl/fl but not LyZ2‐Cre;Trpv2fl/fl BMDCs. Consistently, complement of LRMDA into LyZ2‐Cre;Trpv2fl/fl BMDCs partially restores the tension and mobility of cell membrane and promotes viral penetration and infection. These findings characterize a previously unknown function of myeloid TRPV2 in facilitating viral infection though the Ca2+‐LRMDA axis.

The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca2+‐LRMDA Axis in Myeloid Cells

Interferon (IFN) contributes to the host's antiviral response by inducing IFN-stimulated genes (ISGs). However, their functional targets and the mechanism of action remain elusive. Here, we report that one such ISG, TRIM21, interacts with and degrades the TRPV2 channel in myeloid cells, reducing its expression and providing host protection against viral infections. Moreover, viral infection upregulates TRIM21 in paracrine and autocrine manners, downregulating TRPV2 in neighboring cells to prevent viral spread to uninfected cells. Consistently, the Trim21 

Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21.

Enhanced recovery of tight reservoirs after fracturing by natural gas huff-n-puff: Underlying mechanisms and influential factors

Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115.

Black nanosheets (BNs) and low-salinity water (LSW) flooding are two effective methods for improving oil recovery in low-permeability or ultra-low-permeability petroleum reservoirs. The former focuses on emulsification and interfacial tension reduction, while the latter focuses on wettability alteration. Combining BN with LSW is expected to achieve dual effects in oil recovery. However, there has been no research on the combination effect of BN and LSW on conglomerate reservoirs. Therefore, this study aims to investigate the oil imbibition mechanism of the BN–LSW composite system in the tight reservoir of Mahu Oilfield. The interfacial properties of the BN–LSW composite system were evaluated in terms of the oil–water interfacial tension, crude oil emulsification capability, and three-phase contact angle between oil, water, and rock. Through the imbibition experiment of the natural cores in Mahu Oilfield, the imbibition differences between single systems and the BN–LSW composite system were compared. The results showed that the BN–LSW composite system had minimal impact on the interfacial tension between oil and water compared to formation brine, LSW, and BN solution. However, the composite system demonstrated a significant emulsification effect with Mahu crude oil and alterated the wettability of the core. Compared to the single systems, the imbibition rate of the BN–LSW composite system was higher, resulting in an improved imbibition effect. The NMR T2 signal explained the synergistic core imbibition effect of the BN–LSW composite system at the microscopic scale. The research outcomes of this study can provide a new approach for developing low-permeability and ultra-low-permeability reservoirs, holding practical value and reference significance. 

Black Nanosheet-Enhanced Low-Salinity Water System for Improving Oil Recovery in a Low-Permeability Conglomerate Reservoir

Similarity-based laboratory study of CO2 huff-n-puff in tight conglomerate cores

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The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca2+‐LRMDA Axis in Myeloid Cells

Similarity-based laboratory study of CO2 huff-n-puff in tight conglomerate cores