Yu-Chen Chen
Hebrew University of Jerusalem
14 Papers
34 Citations
Yu-Chen Chen is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 6 publications.
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Papers
Mitogenic Gi protein‐MAP kinase signaling cascade in MC3T3‐E1 osteogenic cells: Activation by C‐terminal pentapeptide of osteogenic growth peptide [OGP(10–14)] and attenuation of activation by cAMP
Nidal Gabarin,Hanna Gavish,Andras Muhlrad,Yu-Chen Chen,M Namdar-Attar,Robert A. Nissenson,Michael Chorev,Itai Bab +7 more
TL;DR: It is demonstrated that OGP(10–14) is the active form of OGP, apparently generated proteolytically in the extracellular milieu upon dissociation of O GP–OGPBP complexes.
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Structure-bioactivity of C-terminal pentapeptide of osteogenic growth peptide [OGP(10-14)]
Yu-Chen Chen,Itai Bab,Nura Mansur,M Namdar-Attar,Hanna Gavish,M Vidson,Andras Muhlrad,A. Shteyer,Michael Chorev +8 more
TL;DR: Data suggest that the integrity of the pharmacophores presented by Tyr and Phe side chains, as well as the Gly residues at the C-terminus, are important for optimal bioactivity of OGP(10-14).
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Isolation of mitogenically active C-terminal truncated pentapeptide of osteogenic growth peptide from human plasma and culture medium of murine osteoblastic cells.
I. Bab,Hanna Gavish,M Namdar-Attar,Andras Muhlrad,Zvi Greenberg,Yu-Chen Chen,Nura Mansur,A. Shteyer,Michael Chorev +8 more
TL;DR: It is concluded that OGP (10-14) is a naturally occurring human and murine mitogen and the data suggests that the OGP(10- 14) is generated from OGP by proteolytic cleavage upon dissociation of the O GP-OGPBP complexes.
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Revolutionizing wound healing: Ultrashort pulse electric fields in seconds for highly aligned extracellular matrix and efficient cell migration
Xiao-Wei Xiang,Hao Liu,Wei Liu,Ze Yan,Yu Zeng,Ya Jun Wang,Jing Liu,Yu-Chen Chen,Saiki Yu,Cai-Hui Zhu,Xiaoqing Tao,Chen Wang,Jin Wu,Yang Du,Xinxiang Xu,Hai Gao,Yaming Jiu,Jian Qiu,Lingqian Chang,Guangyin Jing,Kefu Liu,Yan-Jun Liu +21 more
TL;DR: In this paper , a microsecond pulse electric field (μsPEF) was proposed and realized to promote wound healing under a much short time (seconds) for the total treatment.
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On-chip modeling of physiological and pathological blood-brain barrier microenvironment for studying glial responses to neuroinflammation
Yu-Lian Zeng,Yang Du,Xinxiang Xu,Ya Jun Wang,Saiki Yu,Ting Liu,Shiyuan Luo,Xiao-Wei Xiang,Wei Li,Yu-Chen Chen,Hongjun Huang,Hai Gao,Yuhui Shen,Yan Luo,Chengrong Bao,Yan-Jun Liu +15 more
TL;DR: Researchers developed a microfluidic BBB chip model to study glial responses to neuroinflammation, recapitulating physiological and pathological states, and demonstrated its potential for elucidating brain neurodegenerative disease progression and preclinical drug efficacy evaluation.
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