Yu Chen
Wenzhou Medical College
17 Papers
31 Citations
Yu Chen is an academic researcher from Wenzhou Medical College. The author has contributed to research in topics: Retinal degeneration & Microphthalmia-associated transcription factor. The author has an hindex of 7, co-authored 11 publications. Previous affiliations of Yu Chen include Vision-Sciences, Inc..
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Papers
KIT ligand protects against both light-induced and genetic photoreceptor degeneration.
Huirong Li,Lili Lian,Bo Liu,Yu Chen,Jinglei Yang,Shuhui Jian,Jiajia Zhou,Ying Xu,Xiaoyin Ma,Jia Qu,Ling Hou +10 more
TL;DR: It is shown in mouse models that signaling through the tyrosine kinase receptor KIT protects photoreceptor cells against both light-induced and inherited retinal degeneration.
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Microphthalmia-associated transcription factor acts through PEDF to regulate RPE cell migration
Xiaoyin Ma,Li Pan,Xi Jin,Xi Jin,Xiaodan Dai,Xiaodan Dai,Huirong Li,Huirong Li,Bin Wen,Bin Wen,Yu Chen,Yu Chen,Aobo Ma,Jia Qu,Ling Hou,Ling Hou +15 more
TL;DR: It is suggested that MITF has a novel and important role in maintaining RPE cells as a stable monolayer and the down-regulation of PEDF that may contribute to retinal degenerative diseases.
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High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3
Huirong Li,Bo Liu,Lili Lian,Jiajia Zhou,Shengjin Xiang,Yifan Zhai,Yu Chen,Xiaoyin Ma,Wencan Wu,Ling Hou +9 more
TL;DR: In this paper, the role of HMOX1 expression in light-induced retinal degeneration was investigated in a line of knockout mice and it was shown that the expression levels determine whether HMOx1 is protective or deleterious in the retina.
The transcription factor TBX2 regulates melanogenesis in melanocytes by repressing Oca2.
TL;DR: It is found that α-MSH or forskolin, both of which stimulate melanogenesis, also reduceTBX2 expression, and that specific knockdown of TBX2 increases melanogenesis.
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Aim2 Deficiency Ameliorates Lacrimal Gland Destruction and Corneal Epithelium Defects in an Experimental Dry Eye Model
Yu Chen,Jiheng Pu,Xinda Li,Lili Lian,Chaoxiang Ge,Zuimeng Liu,Weizhuo Wang,Ling Hou,Wei Chen,Jinyang Li +9 more
TL;DR: In this article , the role of AIM2 in the pathogenesis of dry eye disease was investigated in mice with SCOP induced by injection of scopolamine (SCOP).
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