Yu Chen
Wuhan University
91 Papers
281 Citations
Yu Chen is an academic researcher from Wuhan University. The author has contributed to research in topics: Biology & Coronavirus. The author has an hindex of 27, co-authored 82 publications.
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Papers
Emerging coronaviruses: Genome structure, replication, and pathogenesis.
Yu Chen,Qianyun Liu,Deyin Guo +2 more
TL;DR: This review will help understand the biology and potential risk of CoVs that exist in richness in wildlife such as bats and describe diseases caused by different CoVs in humans and animals.
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Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals.
Yuan Liu,Zhi Ning,Yu Chen,Ming Guo,Yingle Liu,Nirmal Kumar Gali,Li Sun,Yusen Duan,Jing Cai,Dane Westerdahl,Xinjin Liu,Ke Xu,Kin Fai Ho,Haidong Kan,Qingyan Fu,Ke Lan +15 more
TL;DR: It is proposed that room ventilation, open space, sanitization of protective apparel, and proper use and disinfection of toilet areas can effectively limit the concentration of SARS-CoV-2 RNA in aerosols, although the infectivity of the virus RNA was not established in this study.
Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.
Yong Xiong,Yuan Liu,Liu Cao,Dehe Wang,Ming Guo,Ao Jiang,Dong Guo,Wenjia Hu,Jiayi Yang,Zhidong Tang,Honglong Wu,Yongquan Lin,Meiyuan Zhang,Qi Zhang,Mang Shi,Yingle Liu,Yu Zhou,Ke Lan,Yu Chen +18 more
TL;DR: The results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/Mip1B.
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RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak.
Liangjun Chen,Weiyong Liu,Qi Zhang,Ke Xu,Guangming Ye,Weichen Wu,Ziyong Sun,Fang Liu,Kailang Wu,Bo Zhong,Mei Yi,Wenxia Zhang,Yu Chen,Yirong Li,Mang Shi,Ke Lan,Yingle Liu +16 more
TL;DR: Phylogenetic analysis indicates that 2019-nCoV is close to coronaviruses (CoVs) circulating in Rhinolophus (Horseshoe bats), and Evolutionary analysis based on ORF1a/1b, S, and N genes suggests2019-n coV is more likely a novel CoV independently introduced from animals to humans.
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Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase
TL;DR: Mutational analysis in a replicon system showed that the N7-MTase activity was important for SARS virus replication/transcription and can thus be used as an attractive drug target to develop antivirals for control of coronaviruses including the deadly Sars virus.
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