Yrjö T. Konttinen
Helsinki University Central Hospital
592 Papers
7.1K Citations
Yrjö T. Konttinen is an academic researcher from Helsinki University Central Hospital. The author has contributed to research in topics: Medicine & Synovial membrane. The author has an hindex of 80, co-authored 592 publications. Previous affiliations of Yrjö T. Konttinen include University of California, Los Angeles & University of Alberta.
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Papers
New collagenolytic enzymes/cascade identified at the pannus-hard tissue junction in rheumatoid arthritis : destruction from above
Yrjö T. Konttinen,A Ceponis,Michiaki Takagi,Mari Ainola,Timo Sorsa,Meeri Sutinen,Tuula Salo,Jian Ma,Seppo Santavirta,Motoharu Seiki +9 more
TL;DR: Results indicate that components of the ternary MT1-MMP/TIMP-2/MMP-2 complex are coexpressed in the normal synovial lining and in its pathological extension on the hyaline articular cartilage.
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The cost-effectiveness of biologics for the treatment of rheumatoid arthritis: a systematic review.
TL;DR: Rituximab was found to be the most cost-effective alternative compared to other biologics among the patients with an insufficient response to TNFi, and standardization of multiattribute utility instruments and a validated standard conversion method for missing utility measures would enable better comparison between CUAs.
Membrane Components of Treponema denticola Trigger Proteinase Release from Human Polymorphonuclear Leukocytes
Y. Ding,Veli-Jukka Uitto,Markus Haapasalo,Kari Lounatmaa,Yrjö T. Konttinen,Tuula Salo,Daniel Grenier,Timo Sorsa +7 more
TL;DR: T. denticola may participate in the PMN-dependent extracellular matrix degradation during the course of periodontal inflammation by triggering the secretion and activation of matrix metalloproteinases.
111
Prevention of deep infection in joint replacement surgery: A review
Esa Jämsen,Ove Furnes,Lars B. Engesæter,Yrjö T. Konttinen,A. Odgaard,Anna Stefánsdóttir,Lars Lidgren +6 more
TL;DR: Monitoring of infection rates on a local, national, and even an international scale is an essential part of quality control and is necessary in order to be able to identify weaknesses in current infection prevention practices.
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•Journal Article
Tumor necrosis factor-alpha (TNF-alpha) in loosening of total hip replacement (THR).
Xu Jw,Yrjö T. Konttinen,Jan Lassus,Natah S,A Ceponis,Svetlana Solovieva,Aspenberg P,Seppo Santavirta +7 more
TL;DR: Findings suggest that the foreign body-type host reaction caused by THR is characterized by the high expression of TNF-alpha, which may contribute to periprosthetic osteolysis and to the loosening of THR.
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