Youzhen Yan
University of Southern California
7 Papers
Youzhen Yan is an academic researcher from University of Southern California. The author has contributed to research in topics: Embryonic stem cell & Homologous recombination. The author has an hindex of 4, co-authored 5 publications.
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Papers
Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts
Ping Li,Chang Tong,Ruty Mehrian-Shai,Li Jia,Nancy Wu,Youzhen Yan,Robert E. Maxson,Eric N. Schulze,Houyan Song,Chih-Lin Hsieh,Martin F. Pera,Qi-Long Ying +11 more
TL;DR: It is shown that rat ES cells can be efficiently derived, propagated, and genetically manipulated in the presence of small molecules that specifically inhibit GSK3, MEK, and FGF receptor tyrosine kinases.
741
Production of p53 gene knockout rats by homologous recombination in embryonic stem cells
TL;DR: The establishment of gene targeting technology in rat ES cells, in combination with advances in genomics and the vast amount of research data on physiology and pharmacology in this species, now provide a powerful new platform for the study of human disease.
Mechanotransduction pathways in articular chondrocytes and the emerging role of estrogen receptor-α
Ning Wang,Yangfan Lu,Benjamin B. Rothrauff,Aojie Zheng,Alexander Lamb,Youzhen Yan,Katelyn E. Lipa,Guanghua Lei,Hang Lin +8 more
TL;DR: In this paper , the authors present a review of the mechanotransduction pathways in chondrocytes and the role of estrogen receptor α (ERα) in mediating biomechanical cues under physiological and pathological conditions.
An optimized proliferation system of embryonic stem cells for generating the rat model with large fragment modification.
TL;DR: In this paper, the authors optimized a 5N-medium for rat embryonic stem cells, which improved the in-vitro cells with better morphology and higher pluripotency.
Induction of site-specific chromosomal translocations in embryonic stem cells by CRISPR/Cas9
Junfeng Jiang,Zhang Li,Xingliang Zhou,Xi Chen,Guanyi Huang,Fengsheng Li,Ruizhe Wang,Nancy Wu,Youzhen Yan,Chang Tong,Sankalp Srivastava,Yue Wang,Houqi Liu,Qi-Long Ying +13 more
TL;DR: It is shown that site-specific chromosomal translocations can be generated in mouse embryonic stem cells (mESCs) via CRISPR/Cas9, and chimeric mice can begenerated by injecting these mESCs into host blastocysts.