Young Sik Cho
Keimyung University
65 Papers
223 Citations
Young Sik Cho is an academic researcher from Keimyung University. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 20, co-authored 64 publications. Previous affiliations of Young Sik Cho include University of Massachusetts Medical School.
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Papers
Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation
Young Sik Cho,Sreerupa Challa,David Moquin,Ryan M.J. Genga,Tathagat Dutta Ray,Melissa J. Guildford,Francis Ka-Ming Chan +6 more
TL;DR: The findings suggest that RIP3 controls programmed necrosis by initiating the pronecrotic kinase cascade, and that this is necessary for the inflammatory response against virus infections.
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Vaccine adjuvants: smart components to boost the immune system
Rakesh Bastola,Gyubin Noh,Taekwang Keum,Santosh Bashyal,Jo-Eun Seo,Jaewoong Choi,Yeonsu Oh,Young Sik Cho,Sangkil Lee +8 more
TL;DR: Different adjuvants have different modes of action and a better understanding of their immunology could provide guidance for the development of novel adjuvant-based vaccines, according to this review.
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RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation.
TL;DR: The results reveal that besides RIP1, Nec-1 also targets other factors crucial for necrosis induction in L929 cells, and high doses of Nec- 1 inhibit other signal transduction pathways such as that for T cell receptor activation.
Design, synthesis, and evaluation of 2-aryl-7-(3',4'-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines as novel PDE-4 inhibitors.
Ikyon Kim,Jong Hwan Song,Chang Min Park,Joon Won Jeong,Hyung Rae Kim,Jin Ryul Ha,Zaesung No,Young Lan Hyun,Young Sik Cho,Nam Sook Kang,Dong Ju Jeon +10 more
TL;DR: Design, synthesis, and biological evaluation of novel series of 2-aryl-7-(3',4'-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines acting as inhibitors of type 4 phosphodiesterase (PDE4) which is known as a good target for the treatment of asthma and COPD are described.
50
HPV E6 antisense induces apoptosis in CaSki cells via suppression of E6 splicing
Cheong-Weon Cho,Haryoung Poo,Young Sik Cho,Min Chul Cho,Kyung Ae Lee,Shin Je Lee,Sue Nie Park,In-Ki Kim,Yong-Keun Jung,Yong Kyung Choe,Young Il Yeom,In Seong Choe,Do Young Yoon +12 more
TL;DR: Results indicate that HPV 16 E6(AS) induces apoptosis in CaSki cells via upregulation of p53 and release of cytochrome c into cytoplasm, consequently activating procaspase-9 and procaspases-3.