Young-Jun Shin
Hanyang University
20 Papers
69 Citations
Young-Jun Shin is an academic researcher from Hanyang University. The author has contributed to research in topics: Nephrotoxicity & Medicine. The author has an hindex of 14, co-authored 20 publications.
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Papers
Modulation of Mitochondrial Function and Autophagy Mediates Carnosine Neuroprotection Against Ischemic Brain Damage
Seung-Hoon Baek,Ah Reum Noh,Kyeong-A Kim,Muhammad Akram,Young-Jun Shin,Eun Sun Kim,Seong-Woon Yu,Arshad Majid,Ok-Nam Bae +8 more
TL;DR: The data suggest that the neuroprotective effect of carnosine is at least partially mediated by mitochondrial protection and attenuation of deleterious autophagic processes, and shed new light on the mechanistic pathways that this exciting neuroProtective agent influences.
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Autophagy-mediated occludin degradation contributes to blood–brain barrier disruption during ischemia in bEnd.3 brain endothelial cells and rat ischemic stroke models
Kyeong-A Kim,Donghyun Kim,Jeong-Hyeon Kim,Young-Jun Shin,Eun Sun Kim,Muhammad Akram,Muhammad Akram,Eun-Hye Kim,Arshad Majid,Seung-Hoon Baek,Ok-Nam Bae +10 more
TL;DR: Evidence is provided that autophagy plays an important role in ischemia-induced occludin degradation and loss of BBB integrity, using in vitro cells and in vivo rat models.
silymarin-loaded solid nanoparticles provide excellent hepatic protection: physicochemical characterization and in vivo evaluation
Kwan Yeol Yang,Duhyeong Hwang,Abid Mehmood Yousaf,Dong Wuk Kim,Young-Jun Shin,Ok-Nam Bae,Yong-II Kim,Jong Oh Kim,Chul Soon Yong,Han-Gon Choi +9 more
TL;DR: Developing a novel silymarin-loaded solid nanoparticle system with enhanced oral bioavailability and an ability to provide excellent hepatic protection for poorly water-soluble drugs using Shirasu porous glass (SPG) membrane emulsification and a spray-drying technique could be a useful system for delivery of poorly water
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Role of Autophagy in Endothelial Damage and Blood-Brain Barrier Disruption in Ischemic Stroke.
Kyeong-A Kim,Donggeun Shin,Jeong-Hyeon Kim,Young-Jun Shin,G K Rajanikant,Arshad Majid,Seung-Hoon Baek,Ok-Nam Bae +7 more
TL;DR: This review focuses on autophagy in endothelial dysfunction in the context of ischemic stroke and potential targets for therapeutic manipulation.
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High Glucose Condition Induces Autophagy in Endothelial Progenitor Cells Contributing to Angiogenic Impairment
Kyeong-A Kim,Young-Jun Shin,Muhammad Akram,Eun Sun Kim,Ko-woon Choi,Hyewon Suh,Chul-Hoon Lee,Ok-Nam Bae +7 more
TL;DR: It is demonstrated that autophagy and mitochondrial impairment were induced in EPCs under high glucose condition, giving a new insight into the mechanism underlying dysfunction of diabetic EPCm, and the development of a new treatment option for cardiovascular complications in diabetic patients.
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