Lincoln, Yvonna, and Egon Guba, "Postpositivism and the Naturalist Paradigm," pp. 14-46 in Yvonna Lincoln and Egon Guba, Naturalistic Inquiry . Beverly Hills, CA: Sage, 1985.*

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.

Parkinson’s disease (PD) coincides with a dramatic loss of dopaminergic neurons within the substantia nigra. A key player in the loss of dopaminergic neurons is oxidative stress. Dopamine (DA) metabolism itself is strongly linked to oxidative stress as its degradation generates reactive oxygen species (ROS) and DA oxidation can lead to endogenous neurotoxins whereas some DA derivatives show antioxidative effects. Therefore, DA metabolism is of special importance for neuronal redox-homeostasis and viability. In this review we highlight different aspects of dopamine metabolism in the context of PD and neurodegeneration. Since most reviews focus only on single aspects of the DA system, we will give a broader overview by looking at DA biosynthesis, sequestration, degradation and oxidation chemistry at the metabolic level, as well as at the transcriptional, translational and posttranslational regulation of all enzymes involved. This is followed by a short overview of cellular models currently used in PD research. Finally, we will address the topic from a medical point of view which directly aims to encounter PD.

/pdf/complexity-of-dopamine-metabolism-kgg8jy8ri3.pdf

Complexity of dopamine metabolism

Early school success seems to depend largely on children entering school ready to learn, and many policy initiatives have highlighted the importance of preparing children for school entry. A new study finds that children’s environment plays a major role in their readiness for school, suggesting that intervention could help boost readiness in at-risk youngsters. The study, conducted by researchers at Laval University, the University of Montreal, and the University of Quebec at Montreal, appears in the November/December 2007 issue of the journal Child Development. It is one of the first studies to consider both environmental and genetic influences on children’s readiness for school. The researchers examined 420 pairs of 5-year-old twins, assessing the children on four measures of school readiness that included identifying colors and shapes; answering questions about spatial position (such as above, below, left, right), relative size (such as smaller, bigger), and order (such as first, middle, last); identifying numbers and counting; and identifying letters and writing. Two years later, the children’s teachers were asked to rate the school achievement of 237 pairs of the twins. Environmental factors shared by twins in the same family–such as family resources and income, parents’ behavior with respect to learning, and the twins’ child care experiences–were responsible for much of the individual difference in the children’s school readiness skills, according to the study. The influence of the environmental factors was seen over and above the influence of genetic factors. These shared factors influenced school readiness in both general and specific ways, that is, they were found to be significant for each component of school readiness, as well for the core abilities underlying overall school readiness. Genetic factors played a significant role in the children’s core abilities underlying the four components of school readiness, but the environment shared by twins of the same family remained the most important factor overall. Both genetic and environmental factors were found to influence the association between children’s school readiness and later school achievement. “Our results have important implications for preventive interventions,” said Michel Boivin, Canada Research Chair in Child Social Development and professor of psychology at Laval University in Quebec City and one of the study’s authors. “They should be seen as a further incentive for continued implementation and evaluation of preventive intervention programs aimed at improving the level of school readiness in children from at-risk families.”

Society for Research in Child Development

Premature ovarian failure (POF) is a major side effect of chemotherapy in young cancer patients. To develop pharmaceutical agents for preserving fertility, it is necessary to understand the mechanisms responsible for chemotherapy-induced follicle loss. Here, we show that treatment with cisplatin, a widely used anticancer drug, depleted the dormant follicle pool in mouse ovaries by excessive activation of the primordial follicles, without inducing follicular apoptosis. Moreover, we show that co-treatment with the antioxidant melatonin prevented cisplatin-induced disruption of the follicle reserve. We quantified the various stages of growing follicles, including primordial, primary, secondary, and antral, to demonstrate that cisplatin treatment alone significantly decreased, whereas melatonin co-treatment preserved, the number of primordial follicles in the ovary. Importantly, analysis of the PTEN/AKT/FOXO3a pathway demonstrated that melatonin significantly decreased the cisplatin-mediated inhibitory phosphorylation of PTEN, a key negative regulator of dormant follicle activation. Moreover, melatonin prevented the cisplatin-induced activating phosphorylation of AKT, GSK3β, and FOXO3a, all of which trigger follicle activation. Additionally, we show that melatonin inhibited the cisplatin-induced inhibitory phosphorylation and nuclear export of FOXO3a, which is required in the nucleus to maintain dormancy of the primordial follicles. These findings demonstrate that melatonin attenuates cisplatin-induced follicle loss by preventing the phosphorylation of PTEN/AKT/FOXO3a pathway members; thus, melatonin is a potential therapeutic agent for ovarian protection and fertility preservation during chemotherapy in female cancer patients.

Melatonin prevents cisplatin-induced primordial follicle loss via suppression of PTEN/AKT/FOXO3a pathway activation in the mouse ovary.

It is well known that cracked teeth occur most frequently in the mandibular molars with large or poor restorations, in those over 50 years of age. However, with increasing knowledge and experience with cracks of teeth, cracks appear to be found frequently in intact teeth without restorations. The aim of this study is to analyze the cases of tooth cracks in a dental hospital in a year, and to find out the characteristic features of cracks of teeth. For 1 year, each tooth that were identified as a cracked tooth was recorded and analyzed in terms of the classification of cavity and restorative material, the nature of opposing tooth, the location in the arch, the age and gender, and the clinical signs and symptoms, and treatment result. Cracked teeth were observed most frequently in the teeth with no restorations (60.4%) and with class I restorations (29.2%). The most prevalent age was in those over 40 years of age (31.2% in their 40s, 26.6% in their 50s) and the prevalence was similar in men (53.9%) and women (46.1%). Cracked teeth were found most frequently in the maxillary molars (33.8% in first molar, 23.4% in second molar) than in the mandibular molars (20.1% in first molar, 16.2% in second molar). 96.1% of the cracked teeth responded to the bite test, and 81.1% of the cracked teeth were observed in the mesiodistal direction. The prevalence of cracked tooth was highest in the intact teeth with no restoration, in maxillary molars, and in those over 40 years of age. When examining a intact maxillary posterior tooth that is sensitive to a bite and thermal change, crack in the mesiodistal direction need to be considered one of the causes.

Analysis of 154 cases of teeth with cracks.

Basic fibroblast growth factor promotes bone marrow stromal cell transplantation-mediated neural regeneration in traumatic brain injury

Purpose: The purpose of this study was to investigate factors affecting resilience in nursing students. Methods: A survey was conducted with 200 nursing students at a college and a university in P city and K city. Data were collected from March 1 to 20, 2017, and analyzed with SPSS PASW 22.0. Result...

/pdf/effect-of-self-esteem-emotional-intelligence-and-43zdhx5mbv.pdf

Effect of Self-Esteem, Emotional Intelligence and Psychological Well-Being on Resilience in Nursing Students

/pdf/a-mother-s-experience-of-hospitalization-of-her-newborn-in-1ochvf2h8y.pdf

A Mother’s Experience of Hospitalization of Her Newborn in the Neonatal Intensive Care Unit

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