Purpose: Pancreatic cancer is almost always lethal, and the only U.S. Food and Drug Administration–approved therapies for it, gemcitabine and erlotinib, produce objective responses in Experimental Design: Patients received 8 g curcumin by mouth daily until disease progression, with restaging every 2 months. Serum cytokine levels for interleukin (IL)-6, IL-8, IL-10, and IL-1 receptor antagonists and peripheral blood mononuclear cell expression of NF-κB and cyclooxygenase-2 were monitored. Results: Twenty-five patients were enrolled, with 21 evaluable for response. Circulating curcumin was detectable as drug in glucuronide and sulfate conjugate forms, albeit at low steady-state levels, suggesting poor oral bioavailability. Two patients showed clinical biological activity. One had ongoing stable disease for >18 months; interestingly, one additional patient had a brief, but marked, tumor regression (73%) accompanied by significant increases (4- to 35-fold) in serum cytokine levels (IL-6, IL-8, IL-10, and IL-1 receptor antagonists). No toxicities were observed. Curcumin down-regulated expression of NF-κB, cyclooxygenase-2, and phosphorylated signal transducer and activator of transcription 3 in peripheral blood mononuclear cells from patients (most of whom had baseline levels considerably higher than those found in healthy volunteers). Whereas there was considerable interpatient variation in plasma curcumin levels, drug levels peaked at 22 to 41 ng/mL and remained relatively constant over the first 4 weeks. Conclusions: Oral curcumin is well tolerated and, despite its limited absorption, has biological activity in some patients with pancreatic cancer.

https://clincancerres.aacrjournals.org/content/clincanres/14/14/4491.full.pdf

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

Epidemiological studies have revealed that a diet rich in plant-derived foods has a protective effect on human health. Identifying bioactive dietary constituents is an active area of scientific investigation that may lead to new drug discovery. Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a flavonoid found in many edible plants (e.g. tea, broccoli, cabbage, kale, beans, endive, leek, tomato, strawberries and grapes) and in plants or botanical products commonly used in traditional medicine (e.g. Ginkgo biloba, Tilia spp, Equisetum spp, Moringa oleifera, Sophora japonica and propolis). Some epidemiological studies have found a positive association between the consumption of foods containing kaempferol and a reduced risk of developing several disorders such as cancer and cardiovascular diseases. Numerous preclinical studies have shown that kaempferol and some glycosides of kaempferol have a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, neuroprotective, antidiabetic, anti-osteoporotic, estrogenic/antiestrogenic, anxiolytic, analgesic and antiallergic activities. In this article, the distribution of kaempferol in the plant kingdom and its pharmacological properties are reviewed. The pharmacokinetics (e.g. oral bioavailability, metabolism, plasma levels) and safety of kaempferol are also analyzed. This information may help understand the health benefits of kaempferol-containing plants and may contribute to develop this flavonoid as a possible agent for the prevention and treatment of some diseases.

A review on the dietary flavonoid kaempferol.

http://www.thehealersbible.com/uploads/1/2/9/0/12907633/biological_activities_of_curcumin.pdf

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.

Curcuma longa L. (Zingiberaceae family) and its polyphenolic compound curcumin have been subjected to a variety of antimicrobial investigations due to extensive traditional uses and low side effects. Antimicrobial activities for curcumin and rhizome extract of C. longa against different bacteria, viruses, fungi, and parasites have been reported. The promising results for antimicrobial activity of curcumin made it a good candidate to enhance the inhibitory effect of existing antimicrobial agents through synergism. Indeed, different investigations have been done to increase the antimicrobial activity of curcumin, including synthesis of different chemical derivatives to increase its water solubility as well ass cell up take of curcumin. This review aims to summarize previous antimicrobial studies of curcumin towards its application in the future studies as a natural antimicrobial agent.

/pdf/a-review-on-antibacterial-antiviral-and-antifungal-activity-2f3upa018c.pdf

A review on antibacterial, antiviral, and antifungal activity of curcumin.

Turmeric (Curcuma longa) is extensively used as a spice, food preservative and colouring material in India, China and South East Asia. It has been used in traditional medicine as a household remedy for various diseases, including biliary disorders, anorexia, cough, diabetic wounds, hepatic disorders, rheumatism and sinusitis. For the last few decades, extensive work has been done to establish the biological activities and pharmacological actions of turmeric and its extracts. Curcumin (diferuloylmethane), the main yellow bioactive component of turmeric has been shown to have a wide spectrum of biological actions. These include its antiinflammatory, antioxidant, anticarcinogenic, antimutagenic, anticoagulant, antifertility, antidiabetic, antibacterial, antifungal, antiprotozoal, antiviral, antifibrotic, antivenom, antiulcer, hypotensive and hypocholesteremic activities. Its anticancer effect is mainly mediated through induction of apoptosis. Its antiinflammatory, anticancer and antioxidant roles may be clinically exploited to control rheumatism, carcinogenesis and oxidative stress-related pathogenesis. Clinically, curcumin has already been used to reduce post-operative inflammation. Safety evaluation studies indicate that both turmeric and curcumin are well tolerated at a very high dose without any toxic effects. Thus, both turmeric and curcumin have the potential for the development of modern medicine for the treatment of various diseases.

Turmeric and curcumin: Biological actions and medicinal applications

La presente invention concerne un extrait d'Acanthopanax Senticosus de Coree, un extrait de proteine, un polysaccharide de proteine brut qui en sont derives, une composition de regulation immunitaire dont il est le principe actif, et leur utilisation. L'invention concerne plus particulierement de tels extraits et derives renforcant l'immunite, hautement efficaces contre les allergies et convenant de ce fait comme principes actifs d'aliments fonctionnels, de cosmetiques et de compositions pharmaceutiques. L'invention concerne enfin, d'une part une composition de regulation immunitaire dont ces extraits et derives constituent le principe actif, et d'autre part l'utilisation de cette composition.

Extrait d'acanthopanax senticosus de coree, extrait de proteine, polysaccharide de proteine brut issu d'acanthopanax senticosus de coree, et compositions de regulation immunitaire les comprenant et leur utilisation

Neolignans from the Fruits of Magnolia obovata Inhibit NO Production and Have Neuroprotective Effects.

상기생은 겨우살이과에 속하는 참나무, 팽나무, 물오리 나 무, 밤나무 및 자작나무에 기생하는 늘푸른떨기 나무로서 우리나 라 전역에 분포하고 산후 요통, 동상, 진정, 통경 및 동맥경화 등 의 치료약으로서 사용되어 왔으며 민간에서는 면역 증강 및 항 암 보조 요법제로 널리 사용되어 왔다. 천연물 유래 항암 및 면 역 활성 물질 연구에서 상기생이 민간에서 함암 및 면역증강제 로 많이 사용됨을 알게 되었으며, 유효성분으로 quercetin, avicularin 등을 함유하고 있다는 것은 이미 보고된바 있다. 또 한 상기생의 트라이테르펜 및 페놀성 성분이 대식세포와 T, B세 포의 면역조절에 관여하고 있음이 보고되었고, 대식세포의 reactive nitrogen intermediate, reactive oxygen intermediate 생 성능 및 탐식능과 NK 세포의 활성능을 증가시킴이 보고되었다 . 이에 저자는 상기생 물추출물이 선천면역과 적응면역에 관여 하는 인자들이 면역조절에 영향을 미치는지 관찰하고자 한다. 대식세포는 외부 병원균의 감염 시 다양한 염증인자 및 항 균물질 분비, 식균작용 등을 통해 host defense에 중요한 역할을 수행한다. 대식세포는 선천면역계 및 적응면역계 모두에서 중요 한 역할을 수행하여 secondary lymphoid organ 뿐 아니라 거의 모든 조직에 광범위하게 분포한다. 또한 병원균 유래 위험인자 등에 반응하여 이들을 제거하고 각종 cytokines, chemokine 및 inflammatory mediators를 생성하여 개체의 다른 면역체계에 생 체 내 감염이나 injury가 있음을 알리는 일차적인 역할을 수행한 다. 대식세포는 IFN-γ등의 사이토카인 수용체를 가지고 있다. 이들은 보체성분, 인터페론, IL-1 및 TNF와 같은 사이토카인을 생산하여 T-세포로부터 생산되는 다양한 사이토카인에 의해 기 능이 증강될 수 있다. 활성화된 대식세포에서 생산되는 NO는 비특이적 숙주방어 기작인 대식작용, 그리고 세균 및 암세포의 증식 억제활성을 보인다. 또한 TNF-α와 같은 사이토카인을 생산 하여 감염초기의 반응에도 관여한다 . 여러 위험인자의 인식에는 다양한 면역 수용체들이 관여하 상기생 물추출물이 대식세포 활성화와 Th1 반응에 미치는 효과

/pdf/effect-of-loranthi-ramuluswatet-extract-on-macrophages-41gh3g96ey.pdf

Effect of Loranthi Ramuluswatet Extract on Macrophages Activation and Th1 Response

Boron Trifluoride Etherate on Alumina‐A Modified Lewis Acid Reagent. Part 6. Synthesis of 2′‐(1‐Acetoxymethyl‐1‐cyclohexen‐3‐yl)‐5′‐ alkylresorcinol Diacetate Derivatives.

Phytochemical investigation on the stems of Pileostegia viburnoides Hook.f.et Thoms led to the isolation of twelve compounds, including two steroids (1 and 10), two fatty compounds (2 and 12), seven triterpenoids (3–9), and one coumarin glycoside (11). 24-methylene-5α-dammara-20(21)-en-3β-yl acetate (5), a rare dammarane-tetracyclic triterpene had been first reported just according to the typical 1H-NMR signals analysis, melting point and optical rotation in 1975. However, the complete and reliable NMR and mass data were still unknown. This is the first time to identify the planar and spatial structures of compound 5 by the analysis of 1D-, 2D-NMR, mass data and other physicochemical properties, as well as by comparison of the spectral data with the literature. Further more, the anti-inflammatory and anti-neuroinflammatory activities of dammarane-type triterpenes 4 and 5 were evaluated.

https://journals.sagepub.com/doi/pdf/10.1177/1934578X1901400127

Chemical Constituents from Stems of Pileostegia viburnoides

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