Youjun Shang
5 Papers
10 Citations
Youjun Shang is an academic researcher. The author has contributed to research in topics: Gene & Interferon. The author has an hindex of 2, co-authored 5 publications.
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Papers
Antiviral responses of ATG13 to the infection of peste des petits ruminants virus through activation of interferon response.
Peng Ma,Lingxia Li,Li Jin,Derong Zhang,Xin Cao,Fucheng Guo,Yongqing Zhao,Jialing Bai,Zhongren Ma,Youjun Shang,Xiao-xia Ma +10 more
TL;DR: It is demonstrated that basal ATG 13 was involved in host antiviral activities against PPRV infection and the over-expression of ATG13 activated IFN production to inhibit PPRv replication in an unconventional fashion.
9
Significance and roles of synonymous codon usage in the evolutionary process of Proteus.
TL;DR: The results suggest that the mutation pressure caused by nucleotide composition constraint serves as a dominant evolutionary dynamic driving evolutionary trend of Proteus spp.
3
The nucleotide usages significantly impact synonymous codon usage in Mycoplasma hyorhinis.
Yaqin Wu,Li Jin,Yicong Li,Derong Zhang,Yongqing Zhao,Yuefeng Chu,Zhongren Ma,Xiao-xia Ma,Youjun Shang +8 more
TL;DR: In this article, five annotated genomes of Mycoplasma hyorhinis were analyzed for clarifying evolutionary dynamics driving the overall codon usage pattern, including nucleotide composition constraint derived from mutation pressure, translational selection involved in natural selection, and strand specific mutational bias represented by different nucleotide skew index.
Basal interferon signaling and therapeutic use of interferons in controlling peste des petits ruminants virus infection.
TL;DR: It is shown that the inhibition of JAK-STAT pathway by JAK I inhibitor can abrogate the anti-PPRV activity of IFNs and provide rationale for therapeutic development of IFN-based treatment against PPRV infection.
Inhibiting pyrimidine biosynthesis impairs Peste des Petits Ruminants Virus replication through depletion of nucleoside pools and activation of cellular immunity
Li Jin,Yicong Li,Feiyang Pu,Huihui Wang,Derong Zhang,Jialin Bai,Youjun Shang,Zhongren Ma,Xiao-xia Ma +8 more
TL;DR: In this article, the authors demonstrate that brequinar and leflunomide (LFM) are two specific inhibitors of DHODH enzyme and 6-azauracil (6-AU) which is an ODase enzyme inhibitor robustly inhibit PPRV replication in HEK293T cell line as well as in peripheral blood mononuclear cells isolated from goat.