Yosuke Okazaki
Okayama University
8 Papers
Yosuke Okazaki is an academic researcher from Okayama University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 2, co-authored 2 publications.
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Papers
Vagus Nerve Stimulation with Mild Stimulation Intensity Exerts Anti-Inflammatory and Neuroprotective Effects in Parkinson's Disease Model Rats.
Ittetsu Kin,Tatsuya Sasaki,Takao Yasuhara,Masahiro Kameda,Takashi Agari,Mihoko Okazaki,Kakeru Hosomoto,Yosuke Okazaki,Satoru Yabuno,Satoshi Kawauchi,Ken Kuwahara,Jun Morimoto,Kyohei Kin,Michiari Umakoshi,Yousuke Tomita,Naoki Tajiri,Cesario V. Borlongan,Isao Date +17 more
TL;DR: In this article, the authors developed a wireless controllable electrical stimulator to examine the efficacy of Vagus nerve stimulation (VNS) on Parkinson's disease (PD) model rats, and evaluated the therapeutic effects of VNS with behavioral and immunohistochemical outcome assays under different stimulation intensity (0.25, 0.5 and 1 mA).
Synergistic therapeutic effects of intracerebral transplantation of human modified bone marrow-derived stromal cells (SB623) and voluntary exercise with running wheel in a rat model of ischemic stroke
Satoru Yabuno,Takao Yasuhara,Takayuki Nagase,Satoshi Kawauchi,Chiaki Sugahara,Yosuke Okazaki,Kakeru Hosomoto,Susumu Sasada,Tatsuya Sasaki,Naoki Tajiri,Cesar V. Borlongan,Isao Date +11 more
TL;DR: In this paper , a combination therapy of intracerebral transplantation of human modified bone marrow-derived MSCs, SB623 cells, and voluntary exercise with running wheel (RW) could exert synergistic therapeutic effects on a rat model of ischemic stroke.
Transplantation of modified human bone marrow‐derived stromal cells affords therapeutic effects on cerebral ischemia in rats
Satoshi Kawauchi,Takao Yasuhara,Kyohei Kin,Satoru Yabuno,Chiaki Sugahara,Takayuki Nagase,Kakeru Hosomoto,Yosuke Okazaki,Yousuke Tomita,Michiari Umakoshi,Tatsuya Sasaki,Masahiro Kameda,Cesario V. Borlongan,Isao Date +13 more
TL;DR: The mechanism of secretory function of transplanted SB623 cells, but not cell-cell interaction as primarily mediating the cells' functional benefits in ischemic stroke is revealed.
Continuous vagus nerve stimulation exerts beneficial effects on rats with experimentally induced Parkinson's disease: Evidence suggesting involvement of a vagal afferent pathway
Kakeru Hosomoto,Tatsuya Sasaki,Takao Yasuhara,Masahiro Kameda,Susumu Sasada,Ittetsu Kin,Ken Kuwahara,Satoshi Kawauchi,Yosuke Okazaki,Satoru Yabuno,Chiaki Sugahara,Koji Kawai,Takayuki Nagase,S Tanimoto,Cesario V. Borlongan,Isao Date +15 more
TL;DR: In this paper , the effects of vagal afferent- or efferent-selective stimulation on Parkinson's disease using continuous electrical stimulation remains to be determined, however, it is shown that continuous VNS promoted neuroprotective and anti-inflammatory effect in experimental PD, highlighting the crucial role of the afferent pathway in mediating these therapeutic outcomes.
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Two Cases of Monozygotic Twins with Early-onset Isolated (DYT1) Dystonia Effectively Treated with Bilateral Globus Pallidus Internus Stimulation
Yosuke Okazaki,Tatsuya Sasaki,Kouji Kawai,Kakeru Hosomoto,Susumu Sasada,Takao Yasuhara,Tomoyuki Akiyama,Yoshiyuki Hanaoka,Isao Date +8 more
TL;DR: Bilateral GPi-DBS was performed in monozygotic twins with DYT1 dystonia at 16 years of age and their symptoms remarkably improved after surgery, and the surgical interventions for each patient are considered.
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