Yosuke Ida
Sapporo Medical University
43 Papers
119 Citations
Yosuke Ida is an academic researcher from Sapporo Medical University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 4, co-authored 23 publications.
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Papers
Prostaglandin F2α Agonists Negatively Modulate the Size of 3D Organoids from Primary Human Orbital Fibroblasts.
TL;DR: 3D tissue culture system may be a suitable strategy for understanding the disease etiology of DUES and indicates that PG analogs have the potential to modulate the ECM network within HOF 3D organoids.
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Omidenepag, a non-prostanoid EP2 receptor agonist, induces enlargement of the 3D organoid of 3T3-L1 cells
TL;DR: Observations indicate that EP2 agonists affect the adipogenesis of 3T3-L1 cells in different manners, as compared to PGF2α, suggesting that OMD may not induce P GF2α related orbital fat atrophy, called the deepening of the upper eyelid sulcus (DUES).
Rosiglitasone and ROCK Inhibitors Modulate Fibrogenetic Changes in TGF-β2 Treated Human Conjunctival Fibroblasts (HconF) in Different Manners
TL;DR: In this article, the effects of Rho-associated coiled-coil containing protein kinase (ROCK) 1 and 2 inhibitor, ripasudil hydrochloride hydrate (Rip), ROCK2 inhibitor, KD025 or rosiglitazone (Rosi) on two-dimensional and three-dimensional (3D) cultured human conjunctival fibroblasts treated by transforming growth factor (TGFβ2) were studied.
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Establishment of appropriate glaucoma models using dexamethasone or TGFβ2 treated three-dimension (3D) cultured human trabecular meshwork (HTM) cells.
TL;DR: In this paper, two-dimensional and three-dimensional (3D) cultures of human trabecular meshwork cells (HTM) were prepared in the presence of 250 nM dexamethasone (DEX) or 5 ng/mL TGFβ2, and characterized by the following analyses; transendothelial electrical resistance (TEER) measurements, FITC dextran permeability, scanning electron microscopy and the expression of the extracellular matrix (ECM) including collagen (COL) including fibronectin (FN), α-
ROCK inhibitors enhance the production of large lipid-enriched 3D organoids of 3T3-L1 cells.
TL;DR: In this article, the effects of ROCK-i on 3D organoid sizes, lipid staining, the mRNA expression of adipogenesis related genes, Pparγ, Cebpa and Leptin, and extracellular matrix (ECM) including collagen (COL) 1, 4 and 6, and fibronectin, and physical stiffness were then conducted.