Yoshitaka Isaka
Osaka University
434 Papers
2.5K Citations
Yoshitaka Isaka is an academic researcher from Osaka University. The author has contributed to research in topics: Medicine & Kidney disease. The author has an hindex of 56, co-authored 379 publications. Previous affiliations of Yoshitaka Isaka include University of Utah & Toray Industries.
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Papers
Molecular intervention with antisense oligodeoxynucleotides (ODNs) in nephrology.
TL;DR: The formation of a triplestrand structure by double-stranded DNA and antiTargeting of ODNs to glomerular cells sense ODNs in the promoter region may result in transcriptional inhibition and non-specific effects of antisense ODNs should be widely used.
Obesity-related proximal tubulopathy: an emerging threat to kidney health
TL;DR: In this article , the authors showed that TFEB (transcription factor EB) is a modulator of PTECs lipotoxicity and exposure to saturated fatty acid enhanced dephosphorylation and nuclear translocation in kidney proximal tubular epithelial cells.
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•Journal Article
Gene therapy and tissue engineering in nephrology and renal transplantation
TL;DR: Recent endeavors concerning the gene therapy of transplant kidney, seeking the renal stem cells and reprogramming factors, and exploring genes related to renal fibrosis are described.
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Effects of alfacalcidol on cardiovascular outcomes according to alkaline phosphatase levels in the J-DAVID trial
Tatsufumi Oka,Yusuke Sakaguchi,Yoshitaka Isaka,Haruka Ishii,Daijiro Kabata,Ayumi Shintani,Shinya Nakatani,Tomoaki Morioka,Katsuhito Mori,Masaaki Inaba,Masanori Emoto,Tetsuo Shoji +11 more
TL;DR: In the Japan Dialysis Active Vitamin D (J-DAVID) trial, oral alfacalcidol numerically, but not significantly, increased the risk of cardiovascular events among patients undergoing hemodialysis as mentioned in this paper .
Vegetable Preference and Prediction of Proteinuria: A Retrospective Cohort Study.
Shingo Ozaki,Ryohei Yamamoto,Maki Shinzawa,Ryohei Tomi,Ryuichi Yoshimura,Kaori Nakanishi,Makoto Nishida,Izumi Nagatomo,Takashi Kudo,Keiko Yamauchi-Takihara,Yoshitaka Isaka,Toshiki Moriyama +11 more
TL;DR: In this article, a retrospective cohort study included 10,819 university workers in Japan who underwent their annual health checkups between January 2005 and March 2013, and an association between vegetable preference and incidence of proteinuria was assessed using Cox proportional-hazards models adjusted for clinically relevant factors.
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