Yoshio Tsuboi
Fukuoka University
362 Papers
1.1K Citations
Yoshio Tsuboi is an academic researcher from Fukuoka University. The author has contributed to research in topics: Medicine & Parkinsonism. The author has an hindex of 44, co-authored 306 publications. Previous affiliations of Yoshio Tsuboi include Brown University & Chiba University.
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Papers
The metric properties of a novel non-motor symptoms scale for Parkinson's disease: Results from an international pilot study.
Kallol Ray Chaudhuri,Pablo Martinez-Martin,Richard G. Brown,Kapil D. Sethi,Fabrizio Stocchi,Per Odin,William G. Ondo,Kazuo Abe,Graeme Macphee,Doug MacMahon,Paolo Barone,Martin Rabey,A Forbes,Kieran Breen,S. Tluk,Y. Naidu,Warren Olanow,Adrian J. Williams,Sue Thomas,David B. Rye,Yoshio Tsuboi,Annette Hand,Anthony H.V. Schapira,Anthony H.V. Schapira +23 more
TL;DR: NMSS can be used to assess the frequency and severity of NMS in PD patients across all stages in conjunction with the recently validated non‐motor questionnaire.
1K
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation
Leonard Petrucelli,Dennis W. Dickson,Kathryn Kehoe,Julie P. Taylor,Heather Snyder,Andrew Grover,Michael De Lucia,Eileen McGowan,Jada Lewis,G. Prihar,Jungsu Kim,Wolfgang H. Dillmann,Susan E. Browne,Alexis Hall,Richard Voellmy,Yoshio Tsuboi,Ted M. Dawson,Benjamin Wolozin,John Hardy,Mike Hutton +19 more
TL;DR: It is reported that CHIP, an ubiquitin ligase that interacts directly with Hsp70/90, induces ubiquitination of the microtubule associated protein, tau, and that diverse of tau lesions in human postmortem tissue were found to be immunopositive for CHIP.
740
Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease.
Jun Sone,Satomi Mitsuhashi,Atsushi Fujita,Takeshi Mizuguchi,Kohei Hamanaka,Keiko Mori,Haruki Koike,Akihiro Hashiguchi,Hiroshi Takashima,Hiroshi Sugiyama,Yutaka Kohno,Yoshihisa Takiyama,Kengo Maeda,Hiroshi Doi,Shigeru Koyano,Hideyuki Takeuchi,Michi Kawamoto,Nobuo Kohara,Tetsuo Ando,Toshiaki Ieda,Yasushi Kita,Norito Kokubun,Yoshio Tsuboi,Kazutaka Katoh,Yoshihiro Kino,Masahisa Katsuno,Yasushi Iwasaki,Mari Yoshida,Fumiaki Tanaka,Ikuo K. Suzuki,Martin C. Frith,Naomichi Matsumoto,Gen Sobue,Gen Sobue +33 more
TL;DR: Long-read sequencing identifies a GGC repeat expansion in NOTCH2NLC that is associated with neuronal intranuclear inclusion disease, a progressive neurodegenerative disorder, and results in abnormal anti-sense transcripts that could contribute to disease pathogenesis.
423
Neuropathology of variants of progressive supranuclear palsy.
TL;DR: Clinical variants in PSP reflect varying anatomical distribution of tau pathology, but they share histopathologic, biochemical and genetic features with typical PSP, which highlights the range of clinical and pathologic presentations of PSP and its variants.
348
Meta‐Analysis of Gut Dysbiosis in Parkinson's Disease
Hiroshi Nishiwaki,Mikako Ito,Tomohiro Ishida,Tomonari Hamaguchi,Tetsuya Maeda,Kenichi Kashihara,Yoshio Tsuboi,Jun Ueyama,Teppei Shimamura,Hiroshi Mori,Ken Kurokawa,Masahisa Katsuno,Masaaki Hirayama,Kinji Ohno +13 more
TL;DR: The variability of gut microbiota across countries prevented us from identifying shared gut dysbiosis in PD, which can be causally associated with gut Dysbiosis.
284