Yoshio Hirabayashi
RIKEN Brain Science Institute
254 Papers
3K Citations
Yoshio Hirabayashi is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Ceramide & Ganglioside. The author has an hindex of 52, co-authored 250 publications. Previous affiliations of Yoshio Hirabayashi include Keio University & Niigata University of Pharmacy and Applied Life Sciences.
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Papers
Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis
Takaaki Matsui,Siripong Thitamadee,Tomoko Murata,Hisaya Kakinuma,Takuji Nabetani,Yoshio Hirabayashi,Yoshikazu Hirate,Hitoshi Okamoto,Yasumasa Bessho +8 more
TL;DR: The results uncover both a previously unidentified role of FGF signaling during vertebrate organogenesis and a regulatory mechanism underlying cell cluster formation, which is an indispensable step for formation of a functional KV and establishment of the left–right asymmetric body plan in zebrafish.
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Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations.
TL;DR: It is suggested that Cer, but not its metabolites, regulates survival and development of spinal motoneurons, depending on its intracellular concentration.
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Association of FcγRII with Low-Density Detergent-Resistant Membranes Is Important for Cross-Linking-Dependent Initiation of the Tyrosine Phosphorylation Pathway and Superoxide Generation
Osamu Katsumata,Miki Hara-Yokoyama,Catherine Sautès-Fridman,Yasuko Nagatsuka,Toshiaki Katada,Yoshio Hirabayashi,Kazufumi Shimizu,Junko Fujita-Yoshigaki,Hiroshi Sugiya,Shunsuke Furuyama +9 more
TL;DR: It is concluded that the cross-linking-dependent association of FcγRII to lipid rafts is important for the activation of F cγR II-associated Src family protein tyrosine kinases to initiate the tyrosinesine phosphorylation cascade leading to superoxide generation.
Complete Removal of Sphingolipids from the Plasma Membrane Disrupts Cell to Substratum Adhesion of Mouse Melanoma Cells
TL;DR: The complex sphingolipids play critical roles in cell to substratum adhesion, and the presence of either GSLs or SM is sufficient for the adhesion.
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Cholesterol glucosylation is catalyzed by transglucosylation reaction of β-glucosidase 1.
TL;DR: Overexpression of β-glucosidase 1 (GBA1, lysosomal acid β-glucocerebrosidase) led to an increase in cholesterol glucosylation activity in human fibroblasts, demonstrating a novel function of GBA1 as a β-ChlGlc-synthesizing enzyme and revealing a new pathway for glycolipid metabolism in mammals.
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