Yoshikazu Higami
Tokyo University of Science
162 Papers
1.1K Citations
Yoshikazu Higami is an academic researcher from Tokyo University of Science. The author has contributed to research in topics: White adipose tissue & Adipose tissue. The author has an hindex of 33, co-authored 157 publications. Previous affiliations of Yoshikazu Higami include University of Wisconsin-Madison & Nagasaki University.
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Papers
Mitochondrial Unfolded Protein Responses in White Adipose Tissue: Lipoatrophy, Whole-Body Metabolism and Lifespan.
TL;DR: The mitochondrial unfolded protein response (UPRmt) is a stress response mediated by the expression of genes such as chaperones, proteases, and mitokines to maintain mitochondrial proteostasis as discussed by the authors.
Hyperglycemia contributes to the development of Leydig cell hyperplasia in male Spontaneously Diabetic Torii rats.
Yoshitomi Nakane,Yoshitomi Nakane,Yusuke Kemmochi,Naoto Ogawa,Tomohiko Sasase,Takeshi Ohta,Yoshikazu Higami,Fumio Fukai +7 more
TL;DR: Results suggest that insulin might decrease the incidence of Leydig cell hyperplasia by reducing Leydigs cell proliferation and the expression of integrins and extracellular matrix proteins through the reduction of serum glucose concentrations in these animals.
Individual evaluation of aging- and caloric restriction-related changes to distinct multimeric complexes of circulating adiponectin by immunoblotting
Masaki Kobayashi,Yuichirou Nezu,Mayu Itoh,Rio Uchida,Tomoya Arikawa,Minami Otsubo,Yuka Nozaki,Ryoma Tagawa,Yuya Fujishima,Norikazu Maeda,Iichiro Shimomura,Yoshikazu Higami +11 more
TL;DR: In this article , the association of aging and caloric restriction with oligomerization of APN in rodent models, using immunoblotting to distinguish multimeric complexes based on molecular sizes.
Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome.
Yuhei Mizunoe,Masaki Kobayashi,Ryoma Tagawa,Yoshimi Nakagawa,Hitoshi Shimano,Yoshikazu Higami +5 more
TL;DR: It is demonstrated that lysosomal dysfunction in WAT and liver underlies part of the obesity-related pathology, raising the possibility that strategies to modulate lysOSomal function may be effective in preventing or treating the metabolic syndrome.
Insulin-like growth factor 2 and insulin-like growth factor binding protein 2 expression in hepatoblastoma
Sharifah Noor Akmal,Sharifah Noor Akmal,Kankatsu Yun,Kankatsu Yun,Janet MacLay,Janet MacLay,Yoshikazu Higami,Yoshikazu Higami,Takayoshi Ikeda,Takayoshi Ikeda +9 more
TL;DR: The results showed that both IGF2 and IGFBP2 transcripts are present in hepatoblastoma and that their expression is inversely correlated with the degree of tumor cell differentiation.