Yosef Yarden
Weizmann Institute of Science
434 Papers
6.5K Citations
Yosef Yarden is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Receptor tyrosine kinase & Signal transduction. The author has an hindex of 117, co-authored 409 publications. Previous affiliations of Yosef Yarden include Amgen & University of Oxford.
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Papers
•Journal Article
Expression of the erbB-2 family of growth factor receptors and their ligands in breast cancers. Implication for tumor biology and clinical behavior.
TL;DR: The abundance of erbB receptors and their ligands in breast cancers points to their functional importance in the pathogenesis and biological behavior of breast cancers and these receptors and ligands may hold a promise for targeted therapy for breast cancer in the future.
95
Systems Biology of Growth Factor‐Induced Receptor Endocytosis
Yaara Zwang,Yosef Yarden +1 more
TL;DR: Clathrin‐mediated endocytosis sorts for degradation of more than 50 different growth factor receptors capable of relaying growth and differentiation signals by means of their cytoplasm‐facing, intrinsic tyrosine kinase activity, which underscores the importance of understanding mechanisms underlying fail‐safe operation (robustness) and fidelity of the pathway.
94
Neu Differentiation Factor Stimulates Phosphorylation and Activation of the Sp1 Transcription Factor
TL;DR: The promoter of the acetylcholine receptor ɛ subunit is examined and a minimal CA-rich sequence is delineated which mediates transcriptional activation by NDF (NDF-response element [NRE]) and may funnel the signaling of the ErbB network into the nucleus.
Patent
Methods and compositions for cancer therapy and for prognosticating responses to cancer therapy
Sarah S. Bacus,Yosef Yarden,Michael Sela +2 more
- 21 Aug 1992
TL;DR: A method for determining the efficacy of a therapeutic agent, in vitro, for a cancer expressing or overexpressing an oncogene product is described in this article, which is particularly useful for finding therapeutic agents that have a binding affinity for cancer that express HER-2/neu.
92
Experimental approaches to hypothetical hormones: Detection of a candidate ligand of the neu protooncogene (growth factor/receptors/tyrosine phosphorylation/ras oncogene)
Yosef Yarden,Robert A. Weinberg +1 more
- 01 Jan 2016
TL;DR: In this paper, a growing list of oncogenes encoding transmembrane tyrosine kinases that have structures reminis- cent of growth factor receptors are unknown using the neu oncogene as a model system, and several experimental approaches for the detection of such hypothetical ligands are developed.
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