Yongqu Lu
Peking University
15 Papers
14 Citations
Yongqu Lu is an academic researcher from Peking University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 6 publications.
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Papers
Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids.
Yunuo Mao,Wei Wang,Jing-wei Yang,Xin Zhou,Yongqu Lu,Junpeng Gao,Xiao Chen Wang,Lu Wen,Wei Fu,Fuchou Tang +9 more
TL;DR: In this article , a robust organoid-based drug screening system was developed to efficiently identify repurposed drugs for colorectal cancer (CRC) by combining the repused drug library and computation based drug prediction, and 34 drugs with anti-CRC effects were identified.
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Relationships of tumor differentiation and immune infiltration in gastric cancers revealed by single-cell RNA-seq analyses
Xin Zhou,Jing-wei Yang,Yongqu Lu,Yanpeng Ma,Yan Meng,Qingqing Li,Junpeng Gao,Zhaoyu Jiang,Limei Guo,Wei Wang,Yun Yan Liu,Lu Wen,Miao Kai,Wei Fu,Fuchou Tang +14 more
TL;DR: Wang et al. as mentioned in this paper performed single-cell RNA-sequencing to reveal the relationship between differentiation status of cancer cells and tumor immune microenvironments in gastric cancer, where they identified the signature genes for both DGC and PDGC and found that signature genes of PDGC strongly enriched in the epithelial-mesenchymal transition (EMT) program.
Downregulation of FABP5 Suppresses the Proliferation and Induces the Apoptosis of Gastric Cancer Cells Through the Hippo Signaling Pathway.
TL;DR: In this article, Fatty acid binding protein 5 (FABP5) has been reported to play an important role in various cancers and was associated with poor histological differentiation and vascular invasion.
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A glycolysis-related two-gene risk model that can effectively predict the prognosis of patients with rectal cancer
Zhenzhen Liu,Zhentao Liu,Xin Zhou,Yongqu Lu,Yan Hong Yao,Wendong Wang,Siyi Lu,Bingyan Wang,Fei Li,Wei Fu +9 more
TL;DR: In this article , the authors constructed a glycolysis-related prognostic model for colon adenocarcinoma (COAD) patients and established a novel two-gene risk model to effectively predict the prognosis of rectal cancer patients.
Characteristic Analysis of Featured Genes Associated With Stemness Indices in Colorectal Cancer.
TL;DR: It is found that the stemness indices were significantly overexpressed in CRC tissues and were associated with patient survival, and the characteristics of the featured genes fit well with CRC pathology and could provide new strategies for individual prevention and treatment.
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