Yongqing Zhang
National Institutes of Health
136 Papers
465 Citations
Yongqing Zhang is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Biology & Regulation of gene expression. The author has an hindex of 44, co-authored 118 publications.
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Papers
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile.
Evi M. Mercken,Seth D. Crosby,Dudley W. Lamming,Lellean JeBailey,Susan M. Krzysik-Walker,Dennis T. Villareal,Miriam Capri,Claudio Franceschi,Yongqing Zhang,Kevin G. Becker,David M. Sabatini,Rafael de Cabo,Luigi Fontana +12 more
TL;DR: It is reported that long‐term CR in humans inhibits the IGF‐1/insulin pathway in skeletal muscle, a key metabolic tissue and identifies promising pathways for therapeutic targets to combat age‐related diseases and promote health in humans.
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Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes
Emmette R. Hutchison,Emmette R. Hutchison,Elisa Mitiko Kawamoto,Dennis D. Taub,Ashish Lal,Kotb Abdelmohsen,Yongqing Zhang,William H. Wood,Elin Lehrmann,Simonetta Camandola,Kevin G. Becker,Myriam Gorospe,Mark P. Mattson +12 more
TL;DR: In this paper, the miR-181 family is found to be developmentally regulated and present in high amounts in astrocytes compared to neurons, and miR181 expression is altered by exposure to lipopolysaccharide (LPS), a model of inflammation, in both wild-type and transgenic mice lacking both receptors for the inflammatory cytokine TNFα.
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SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
Evi M. Mercken,Sarah J. Mitchell,Sarah J. Mitchell,Sarah J. Mitchell,Alejandro Martin-Montalvo,Robin K. Minor,Maria Almeida,Ana P. Gomes,Morten Scheibye-Knudsen,Hector H. Palacios,Jordan J Licata,Yongqing Zhang,Kevin G. Becker,Husam Khraiwesh,José A. González-Reyes,José M. Villalba,Joseph A. Baur,Peter J. Elliott,Christoph H. Westphal,George P. Vlasuk,James L. Ellis,David A. Sinclair,Michel Bernier,Rafael de Cabo +23 more
TL;DR: It is shown that SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet, accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensitivity associated with higher mitochondrial content and decreased inflammation.
Altered Extracellular Vesicle Concentration, Cargo, and Function in Diabetes.
David W. Freeman,Nicole Noren Hooten,Erez Eitan,Jamal Green,Nicolle A. Mode,Monica Bodogai,Yongqing Zhang,Elin Lehrmann,Alan B. Zonderman,Arya Biragyn,Josephine M. Egan,Kevin G. Becker,Mark P. Mattson,Ngozi Ejiogu,Michele K. Evans +14 more
TL;DR: It is found that insulin resistance increases the secretion of EVs, which are preferentially internalized by leukocytes, and alters leukocyte function, and collectively, these results suggest that insulin resistant people have higher levels of EVs.
Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis
Harald F. Langer,Eun-Young Choi,Eun-Young Choi,Eun-Young Choi,Hong Zhou,Rebecca Schleicher,Kyoung-Jin Chung,Kyoung-Jin Chung,Zhongshu Tang,Kerstin Göbel,Khalil Bdeir,Antonios Chatzigeorgiou,Connie H.Y. Wong,Sumeena Bhatia,Michael J. Kruhlak,John W. Rose,James Burns,Kenneth E. Hill,Hongchang Qu,Yongqing Zhang,Elin Lehrmann,Kevin G. Becker,Yunmei Wang,Daniel I. Simon,Bernhard Nieswandt,John D. Lambris,Xuri Li,Sven G. Meuth,Paul Kubes,Triantafyllos Chavakis,Triantafyllos Chavakis +30 more
TL;DR: Platelets contribute to the pathogenesis of EAE by promoting CNS inflammation by promoting platelet adhesion and inflammatory actions of platelets and targeting of GPIb&agr; attenuated EAE in mice resulted in significantly ameliorated disease development and progression.
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