23 Papers
12 Citations
Yong Sun is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Vascular smooth muscle & Calcification. The author has an hindex of 12, co-authored 16 publications. Previous affiliations of Yong Sun include Veterans Health Administration.
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Papers
Smooth Muscle Cell-Specific Runx2 Deficiency Inhibits Vascular Calcification
Yong Sun,Chang Hyun Byon,Kaiyu Yuan,Jianfeng Chen,Xia Mao,Jack M. Heath,Amjad Javed,Kui Zhang,Peter G. Anderson,Yabing Chen +9 more
TL;DR: The functional role of SMC-derived Runx2 is defined in regulating vascular calcification and promoting infiltration of macrophages into the calcified lesion to form osteoclast-like cells, paralleling the bone remodeling process.
307
Runx2-Upregulated Receptor Activator of Nuclear Factor κB Ligand in Calcifying Smooth Muscle Cells Promotes Migration and Osteoclastic Differentiation of Macrophages
Chang Hyun Byon,Yong Sun,Jianfeng Chen,Kaiyu Yuan,Xia Mao,Jack M. Heath,Peter G. Anderson,Yin Tintut,Linda L. Demer,Deli Wang,Yabing Chen +10 more
TL;DR: It is demonstrated that Runx2 directly binds to the promoter and controls the expression of RANKL, which mediates the crosstalk between calcifying VSMC and migration and differentiation of macrophages into osteoclast-like cells in the atherosclerotic lesions.
168
Activation of AKT by O-Linked N-Acetylglucosamine Induces Vascular Calcification in Diabetes Mellitus
Jack M. Heath,Yong Sun,Kaiyu Yuan,Wayne E. Bradley,Silvio H. Litovsky,Louis J. Dell'Italia,John C. Chatham,Hui Wu,Yabing Chen +8 more
TL;DR: In this article, the role of protein O-GlcNAcylation in regulating vascular calcification and the underlying mechanisms were investigated in diabetic mice with low-dose streptozotocin-induced diabetic mice.
145
Inhibition of FOXO1/3 Promotes Vascular Calcification
TL;DR: A new causative effect of SMC-specific PTEN deficiency on vascular calcification is determined and it is demonstrated that FOXO1/3 plays a crucial role in PTEN/AKT-modulated Runx2 ubiquitination and VSMC calcification.
113
Runx2 (Runt-Related Transcription Factor 2)-Mediated Microcalcification Is a Novel Pathological Characteristic and Potential Mediator of Abdominal Aortic Aneurysm.
Zhiqing Li,Zuoquan Zhao,Zeyu Cai,Yong Sun,Li Li,Fang Yao,Liu Yang,Yuan Zhou,Haibo Zhu,Yi Fu,Li Wang,Wei Fang,Yabing Chen,Wei Kong +13 more
TL;DR: The studies have revealed microcalcification as a novel pathological characteristic and potential mediator of AAA, and targeting microCalcification may represent a promising strategy for AAA prevention and treatment.
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