Yolanda Vankan
Erasmus University Rotterdam
6 Papers
163 Citations
Yolanda Vankan is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Virus Integration & Gene. The author has an hindex of 6, co-authored 6 publications.
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Papers
Anandamide, a Natural Ligand for the Peripheral Cannabinoid Receptor Is a Novel Synergistic Growth Factor for Hematopoietic Cells
Peter J. M. Valk,Sandra E. Verbakel,Yolanda Vankan,Samantha Hol,Shanta Mancham,Rob E. Ploemacher,Angelique E. M. Mayen,Bob Löwenberg,Ruud Delwel +8 more
TL;DR: Transfection experiments of Cb2 in myeloid 32D cells showed that anandamide specifically activates proliferation through activation of the peripheral cannabinoid receptor, and Anandamide appears to be a novel and synergistic growth stimulator for hematopoietic cells.
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The genes encoding the peripheral cannabinoid receptor and alpha-L-fucosidase are located near a newly identified common virus integration site, Evi11.
Peter J. M. Valk,Samantha Hol,Yolanda Vankan,J. N. Ihle,David S. Askew,N. A. Jenkins,D. J. Gilbert,N. G. Copeland,N. J. De Both,Bob Löwenberg,Ruud Delwel +10 more
TL;DR: The data suggest that the peripheral cannabinoid receptor gene might be involved in leukemogenesis as a result of aberrant expression of Cnr2 due to retroviral integration in Evi11.
Erythroid defects and increased retrovirally-induced tumor formation in Evi1 transgenic mice.
D Louz,M. Van Den Broek,Sandra E. Verbakel,Yolanda Vankan,K. van Lom,Marieke Joosten,D Meijer,Bob Löwenberg,Ruud Delwel +8 more
TL;DR: The results present the first evidence of Evi1 disturbing normal erythropoiesis in vivo and provides evidence for cooperative potential ofevi1 in tumor progression and indicates an increased susceptibility for leukemia development.
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Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2.
Peter J. M. Valk,Yolanda Vankan,Marieke Joosten,Nancy A. Jenkins,Neal G. Copeland,Bob Löwenberg,Ruud Delwel +6 more
TL;DR: It is shown that Cnr2 is a frequent target for insertion of Cas-Br-M murine leukemia virus (MuLV) in primary tumors in NIH/Swiss mice, and multiple provirus insertions in Evi11 were cloned and shown to be located within the 3′ untranslated region of the candidate proto-oncogene Cnr 2.
Phenotyping of Evi1, Evi11/Cb2, and Evi12 transformed leukemias isolated from a novel panel of cas-Br-M murine leukemia virus-infected mice.
TL;DR: A panel of well characterized Cas-Br-M MuLV-induced hematopoietic tumors may be useful for the isolation and characterization of new proto-oncogenes involved in myeloid or T-cell leukemias.
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