Yoichiro Uchida
Kyoto University
73 Papers
104 Citations
Yoichiro Uchida is an academic researcher from Kyoto University. The author has contributed to research in topics: Medicine & Liver transplantation. The author has an hindex of 18, co-authored 37 publications. Previous affiliations of Yoichiro Uchida include Kansai Medical University & University of California, Los Angeles.
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Papers
T-Cell Immunoglobulin Mucin-3 Determines Severity of Liver Ischemia/Reperfusion Injury in Mice in a TLR4-Dependent Manner
Yoichiro Uchida,Bibo Ke,Maria Cecilia S. Freitas,Hideo Yagita,Hisaya Akiba,Ronald W. Busuttil,Nader Najafian,Jerzy W. Kupiec-Weglinski +7 more
TL;DR: TIM-3-TLR4 cross-regulation determined the severity of liver IRI in TLR4-dependent manner; these findings provide important information about the modulation of innate vs adaptive responses in patients that received liver transplants.
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The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury.
Yoichiro Uchida,Maria Cecilia S. Freitas,Danyun Zhao,Ronald W. Busuttil,Jerzy W. Kupiec-Weglinski +4 more
TL;DR: Sivelestat-mediated NE inhibition may represent an effective therapeutic option in liver transplantation and other inflammation disease states and in vitro studies confirmed downregulation of proinflammatory cytokine and chemokine programs in mouse macrophage cell cultures.
Programmed death-1/B7-H1 negative costimulation protects mouse liver against ischemia and reperfusion injury†‡
Haofeng Ji,Xiu-Da Shen,Feng Gao,Bibo Ke,Maria Cecilia S. Freitas,Yoichiro Uchida,Ronald W. Busuttil,Yuan Zhai,Jerzy W. Kupiec-Weglinski +8 more
TL;DR: This study is the first to demonstrate that stimulating PD‐1 signals ameliorated liver IRI by inhibiting T cell activation and Kupffer cell/macrophage function, and may be instrumental in the maintenance of hepatic homeostasis by minimizing organ damage and promoting IL‐10–dependent cytoprotection.
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The Membrane Attack Complex (C5b-9) in Liver Cold Ischemia and Reperfusion Injury
Constantino Fondevila,Constantino Fondevila,Xiu-Da Shen,Sei-ichiro Tsuchihashi,Yoichiro Uchida,Maria Cecilia S. Freitas,Bibo Ke,Ronald W. Busuttil,Jerzy W. Kupiec-Weglinski +8 more
TL;DR: This is the first report using a clinically relevant liver cold ischemia model to show that local MAC inhibition attenuates IRI cascade in OLT recipients and the terminal products of the complement system are essential in the mechanism of hepatic IRI.
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The inhibition of neutrophil elastase ameliorates mouse liver damage due to ischemia and reperfusion
Yoichiro Uchida,Maria Cecilia S. Freitas,Danyun Zhao,Ronald W. Busuttil,Jerzy W. Kupiec-Weglinski +4 more
TL;DR: Targeting neutrophil elastase represents a useful approach for preventing liver IRI and hence expanding the organ donor pool and improving the overall success of liver transplantation.
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