Yoav Ben-Shlomo

TL;DR: The authors' APOE-stratified GWAS is the first to show GWS association for AD with SNPs in the chromosome 17q21.31 region, and the finding in the stage 1 sample that AD risk is significantly influenced by the interaction of APOE with TMEM106B (P=1·6 × 10−7) is noteworthy, because TMEM 106B variants have previously been associated with risk of frontotemporal dementia.

TL;DR: Older age, smoking, and adiposity were consistently associated with higher VTE risk, and there was inconsistent associations of VTEs with diabetes and blood pressure across ERFC and UK Biobank.

TL;DR: Initial treatment with the dopamine agonist bromocriptine did not reduce mortality or motor disability and the initially reduced frequency in motor complications was not sustained and no evidence of a long-term benefit or clinically relevant disease-modifying effect was found.

TL;DR: Rivastigmine can improve gait stability and might reduce the frequency of falls, and a phase 3 study is needed to confirm these findings and show cost-effectiveness of rivastIGmine treatment.