Yiyi Chen
University of Tübingen
14 Papers
12 Citations
Yiyi Chen is an academic researcher from University of Tübingen. The author has contributed to research in topics: Retinal & Biology. The author has an hindex of 2, co-authored 4 publications.
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Papers
The role of cGMP-signalling and calcium-signalling in photoreceptor cell death: perspectives for therapy development.
Soumyaparna Das,Yiyi Chen,Jie Yan,Gustav Christensen,Soumaya Belhadj,Arianna Tolone,François Paquet-Durand +6 more
TL;DR: The second messengers, cGMP and Ca2+, have both been implicated in retinal degeneration; however, it is still unclear which of the two messengers is most relevant for photoreceptor cell death as mentioned in this paper.
Expression of glucose transporter-2 in murine retina: Evidence for glucose transport from horizontal cells to photoreceptor synapses.
Ming Yang,Ming Yang,Yiyi Chen,Stavros Vagionitis,Elod Kortvely,Marius Ueffing,Oliver Schmachtenberg,Zhulin Hu,Kangwei Jiao,François Paquet-Durand +9 more
TL;DR: In this paper, the authors used immunofluorescence to show that glucose transporter-2 (GLUT2) is expressed in horizontal cells of the mouse neuroretina in proximity to inner retinal capillaries.
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Blood–Brain Barrier Breakdown is a Sensitive Biomarker of Cognitive and Language Impairment in Patients with White Matter Hyperintensities
Xing Wang,Yulu Shi,Yiyi Chen,Ying Gao,Tingting Wang,Zhengyang Li,Yilong Wang +6 more
TL;DR: Increased BBB permeability in PVWMH and DWMH was significantly associated with lower cognitive and language function after adjustment for age, education level (EL) and intracranial volume (ICV), and in the CI group, this correlation remained significant.
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Imaging of lactate metabolism in retinal Müller cells with a FRET nanosensor
Víctor Calbiague García,Yiyi Chen,Bárbara Cadiz,François Paquet Durand,Oliver Schmachtenberg +4 more
TL;DR: Pharmacological manipulation with specific monocarboxylate transporter (MCT) inhibitors and immunohistochemistry revealed the functional expression of MCT2 and MCT4 in Müller cells and the introduction of nanosensors to measure key metabolites at the cellular level may contribute to a better understanding of heretofore poorly understood issues in retinal metabolism.
Pathomechanisms of Inherited Retinal Degeneration and Perspectives for Neuroprotection.
Arianna Tolone,Merve Sen,Yiyi Chen,Marius Ueffing,Blanca Arango-Gonzalez,François Paquet Durand +5 more
TL;DR: The current knowledge on photoreceptor degenerative mechanisms is reviewed, focusing on processes triggered by aberrant cGMP-signaling, proteostasis, and energy metabolism, and how these pathways could potentially be used to treat photorecept degeneration.
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