Yisui Xia
University of Minnesota
7 Papers
29 Citations
Yisui Xia is an academic researcher from University of Minnesota. The author has contributed to research in topics: Helicase & Protein methylation. The author has an hindex of 5, co-authored 5 publications.
Chat about Author
Papers
hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity.
Li Wan,Jiangman Lou,Yisui Xia,Bei Su,Ting Liu,Jiamin Cui,Yingying Sun,Huiqiang Lou,Jun Huang +8 more
TL;DR: HPrimpol1 is a novel factor involved in the response to DNA replication stress and both RPA1 binding and the primase activity of hPrimPol1 are required for its cellular function during DNA replication.
A Prototypic Lysine Methyltransferase 4 from Archaea with Degenerate Sequence Specificity Methylates Chromatin Proteins Sul7d and Cren7 in Different Patterns
Yanling Niu,Yisui Xia,Sishuo Wang,Jiani Li,Caoyuan Niu,Xiao Li,Yuehui Zhao,Huiyang Xiong,Zhen Li,Huiqiang Lou,Qinhong Cao +10 more
TL;DR: It is shown that a widespread lysine methyltransferase from Archaea (aKMT4), bears striking structural and functional resemblance to the core of distantly related eukaryotic KMT4/Dot1, and may be regulated by the local chromatin environment, albeit as a promiscuous enzyme required for extensive and variegated lysines methylation in Sulfolobus.
30
DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans
Yisui Xia,Remi Sonneville,M. Jenkyn-Bedford,Liqin Ji,Constance Alabert,Ye Hong,Joseph T.P. Yeeles,Karim Labib +7 more
TL;DR: Caenorhabditis elegans DNSN-1, the ortholog of human DONSON, functions during helicase assembly in a complex with MUS-101/TOPBP1, and is identified as a missing link in the understanding of DNA replication initiation, suggesting that initiation defects underlie the human disease syndrome that results from DONSON mutations.
Mutations in RECQL Gene Are Associated with Predisposition to Breast Cancer.
Jie Sun,Yuxia Wang,Yisui Xia,Ye Xu,Tao Ouyang,Jinfeng Li,Tianfeng Wang,Zhaoqing Fan,Tie Fan,Benyao Lin,Huiqiang Lou,Yuntao Xie +11 more
TL;DR: Se sequencing the entire exomes of nine early-onset familial breast cancer patients without BRCA1/2 mutations found that two index cases carried a potentially deleterious mutation in the RECQL gene (RecQ helicase-like; chr12p12), suggesting that RECQL is a potential breast cancer susceptibility gene and that mutations in this gene contribute to familial Breast cancer development.
Cohesin in DNA damage response and double-strand break repair
TL;DR: This review sums up recent progress on how cohesin regulates the DNA damage checkpoint activation and repair pathway choice, emphasizing postreplicative cohesIn loading and DI-cohesion establishment in yeasts and mammals.