Yinon Shafrir
National Institutes of Health
8 Papers
81 Citations
Yinon Shafrir is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Calcium channel & Calcium in biology. The author has an hindex of 8, co-authored 8 publications.
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Papers
Models of Membrane-bound Alzheimer’s Abeta Peptide Assemblies
TL;DR: These models were developed to be consistent with microscopy studies of Aβ assemblies in membranes, one of which is presented here for the first time and explains why the channels are selective for cations and how metal ions may block channels or inhibit formation of channels.
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Beta-barrel models of soluble amyloid beta oligomers and annular protofibrils
TL;DR: This work presents models of soluble hexameric assemblies of Aβ42 and suggests how they can lead to larger assemblies and eventually to fibrils.
Models of voltage-dependent conformational changes in NaChBac channels.
TL;DR: Models of the transmembrane region of the NaChBac channel were developed in two open/inactivated and several closed conformations to account for the large gating charge movement reported for NaCh Bac channels and for experimental results in other voltage-gated channels.
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Polyhistidine peptide inhibitor of the Abeta calcium channel potently blocks the Abeta-induced calcium response in cells. Theoretical modeling suggests a cooperative binding process.
TL;DR: It is found that a small four-histidine peptide, NAHis04, potently inhibits the Abeta-induced calcium channel currents in artificial lipid membranes and also potently blocks the intracellular calcium increase which is observed in cells exposed to Abeta.
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Models of the structure and gating mechanisms of the pore domain of the NaChBac ion channel.
TL;DR: Structural models of the NaChBac channel in closed and open conformations are developed, using K(+)-channel crystal structures as initial templates, which may serve as a stepping stone between K(+) channels of known structure and Na(V), Ca(V, and TRP channels of unknown structure.
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