Ying Yao

TL;DR: In this article , the crystal structures of human non-specific alkaline phosphatase (TNAP) were determined at near-atomic resolution and mapped the major pathogenic mutations onto the structure.

TL;DR: Xu et al. as discussed by the authors developed the first on-DNA meeting diaryliodonium salts (DAI) chemistry and realized the selective arylation of phenols and oximes with both high yield and DNA fidelity via substrate activation strategy.

TL;DR: The use of “substrate activation” approach to address the arylation of DNA‐conjugated phenols is described and the new on‐DNA diaryliodonium salts chemistry affords a greater flexibility in DEL design and synthesis.

TL;DR: The nDEL hit, kaempferol, represents a novel chemical scaffold capable of specifically recognizing TNF‐α and blocking its signal transduction, a promising starting point for the development of a small molecule TNF-α inhibitor for use in the clinical setting.