Ying Xiao
20 Papers
15 Citations
Ying Xiao is an academic researcher. The author has contributed to research in topics: Downregulation and upregulation & Medicine. The author has an hindex of 5, co-authored 11 publications.
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Papers
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy
Yuxia Zhou,Lu Liu,Bangming Jin,Yixuan Wu,Lifen Xu,Xuebing Chang,Laying Hu,Guifang Wang,Yali Huang,Lingyu Song,Ting Zhang,Yuanyuan Wang,Ying Xiao,Fan Zhang,Mingjun Shi,Lingling Liu,Tuan Lao Wang,Rui Yan,Bing Guo +18 more
TL;DR: In this paper , the Meteorin-like (Metrnl) gene product mediates lipid accumulation in the kidney and has therapeutic potential for diabetic kidney disease (DKD) and has been shown to be a stress-responsive regulator of kidney pathophysiology.
Regulation of PTEN/AKT/FAK pathways by PPARγ impacts on fibrosis in diabetic nephropathy.
TL;DR: The results showed that PPARγ regulated the expression of PTEN at a transcriptional level and further regulated EMT and TIF, and this dual activity could regulate the phosphorylation level of AKT and FAK and also affect FAK transcription.
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BMP-7 ameliorates partial epithelial-mesenchymal transition by restoring SnoN protein level via Smad1/5 pathway in diabetic kidney disease
Wei Peng,Xingcheng Zhou,Tingting Xu,Yanwen Mao,Xiaohuan D. Zhang,Huiming Liu,Luqun Liang,Lingling Liu,Lirong Liu,Ying Xiao,Fan Zhang,Shuangbao Li,Mingjun Shi,Yuxia Zhou,Lei Tang,Yuanyuan Wang,Bing Guo +16 more
TL;DR: In this paper , the authors demonstrated that BMP-7 upregulated the expression of endogenous SnoN against renal TIF induced by TGF-β1 or hyperglycemia.
Smad2 and Smad3 play antagonistic roles in high glucose-induced renal tubular fibrosis via the regulation of SnoN.
Yuanyuan Wang,Xiaohuan Zhang,Yanwen Mao,Luqun Liang,Lingling Liu,Wei Peng,Huiming Liu,Ying Xiao,Yingying Zhang,Fan Zhang,Mingjun Shi,Lirong Liu,Bing Guo +12 more
TL;DR: It is demonstrated that Smad3 could inhibit SnoN expression and increase ECM deposition in NRK52E cells, to promote high glucose-induced renal tubular fibrosis, and Smad2 could induce SnoNexpression and reduce ECM depositing, to inhibit high fructose corn syrup-induced fibrosis.
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Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation
Huifang Zhang,Huiming Liu,Jiayi Xiang,Xingcheng Zhou,Dan Wan,Rongyu Chen,Wan-Lin Tan,Luqun Liang,Lingling Liu,Mingjun Shi,Fan Zhang,Ying Xiao,Yuxia Zhou,Ting Zhang,Lei Tang,Bing Guo,Yuanyuan Wang +16 more
TL;DR: The protective effect of ALM on DKD and its possible potential targets are revealed: ALM ameliorates mitochondrial dysfunction and regulates the CDX2/CFTR/β-catenin signaling axis through upregulation and activation of RXRα.
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