11 Papers
25 Citations
Ying Liu is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Dopaminergic. The author has an hindex of 9, co-authored 11 publications. Previous affiliations of Ying Liu include Johns Hopkins University.
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Papers
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.
David Ramonet,João Paulo Lima Daher,João Paulo Lima Daher,Brian M. Lin,Klodjan Stafa,Jaekwang Kim,Jaekwang Kim,Rebecca Banerjee,Marie Westerlund,Olga Pletnikova,Liliane Glauser,Lichuan Yang,Ying Liu,Deborah A. Swing,M. Flint Beal,Juan C. Troncoso,J. Michael McCaffery,Nancy A. Jenkins,Nancy A. Jenkins,Neal G. Copeland,Neal G. Copeland,Dagmar Galter,Bobby Thomas,Michael K. Lee,Michael K. Lee,Ted M. Dawson,Valina L. Dawson,Darren J. Moore +27 more
TL;DR: This study demonstrates that expression of G2019S mutant LRRK2 induces the degeneration of nigrostriatal pathway dopaminergic neurons in an age-dependent manner, and will provide important tools for understanding the mechanism(s) through which familial mutations precipitate neuronal degeneration and PD.
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo
Emanuela Colla,Philippe Coune,Ying Liu,Olga Pletnikova,Juan C. Troncoso,Takeshi Iwatsubo,Bernard L. Schneider,Michael K. Lee,Michael K. Lee +8 more
TL;DR: The data indicate that the accumulation αS within ER leads to chronic ER stress conditions that contribute to neurodegeneration in α-synucleinopathies, and treatment with Salubrinal, an anti-ERS compound, significantly attenuates disease manifestations in both the A53TαS Tg mouse model and the adeno-associated virus-transduced rat model.
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Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.
Ying Liu,Mi Jeong Yoo,Alena Savonenko,Wanda Stirling,Donald L. Price,David R. Borchelt,David R. Borchelt,Laura A. Mamounas,Laura A. Mamounas,W. Ernest Lyons,W. Ernest Lyons,Mary E. Blue,Michael K. Lee +12 more
TL;DR: The results show that a transgenic mouse model of Aβ pathology develops progressive MAergic neurodegeneration occurring in AD cases, and it is shown that the progression forebrain Aβ deposition in the APPswe/PS1ΔE9 model is associated with progressive losses of the forebrain MAergic afferents.
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Differential Expression of Vitreous Proteins in Young and Mature New Zealand White Rabbits.
TL;DR: This study sought to characterize changes in the proteome of vitreous humor related to compartments or age in New Zealand white rabbits and found that carbonic anhydrase III, lambda crystallin, alpha crystallin A and B, beta crystallin B1 and B2 were more abundant in the anterior region, whereas vimentin was less abundant inThe anterior region.
Passive (Amyloid-β) Immunotherapy Attenuates Monoaminergic Axonal Degeneration in the AβPPswe/PS1dE9 Mice
Ying Liu,Michael K. Lee,Michael K. Lee,Maria M. James,Donald L. Price,David R. Borchelt,David R. Borchelt,Juan C. Troncoso,Esther S. Oh +8 more
TL;DR: It is demonstrated that lowering of Aβ levels via passive Aβ immunotherapy ameliorates ongoing degenerative processes, supporting a causal link between Aβ and neurodegeneration.
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