18 Papers
38 Citations
Ying Lin is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Cytotoxic T cell & Cancer research. The author has an hindex of 14, co-authored 17 publications.
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Papers
Prostaglandin E2 Induces FOXP3 Gene Expression and T Regulatory Cell Function in Human CD4+ T Cells
Felicita Baratelli,Ying Lin,Li Zhu,Seok-Chul Yang,Nathalie Heuzé-Vourc'h,Gang Zeng,Karen L. Reckamp,Mariam Dohadwala,Sherven Sharma,Steven M. Dubinett +9 more
TL;DR: PGE2 enhances the in vitro inhibitory function of human purified CD4+CD25+ T reg cells and induces a regulatory phenotype in CD4-CD25− T cells, the first report indicating that PGE2 can modulate FOXP3 expression and T reg function in human lymphocytes.
Specific Inhibition of Cyclooxygenase 2 Restores Antitumor Reactivity by Altering the Balance of IL-10 and IL-12 Synthesis
Marina Stolina,Sherven Sharma,Ying Lin,Mariam Dohadwala,Brian Gardner,Jie Luo,Li Zhu,Mitchell Kronenberg,Patrice W. Miller,Joseph Portanova,Jason C. Lee,Steven M. Dubinett +11 more
TL;DR: Abrogation of COX-2 expression promotes antitumor reactivity by restoring the balance of IL-10 and IL-12 in vivo by down-regulating production of this potent immunosuppressive cytokine.
Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer
Mariam Dohadwala,Seok-Chul Yang,Jie Luo,Sherven Sharma,Raj K. Batra,Min Huang,Ying Lin,Lee Goodglick,Kostyantyn Krysan,Michael C. Fishbein,Longsheng Hong,Chi Lai,Robert B. Cameron,Robert M. Gemmill,Harry A. Drabkin,Steven M. Dubinett +15 more
TL;DR: It is reported that COX-2-dependent pathways contribute to the modulation of E-cadherin expression in NSCLC and that blocking PGE(2) production or activity may contribute to both prevention and treatment of NSCLCs.
298
•Journal Article
Tumor cyclooxygenase 2-dependent suppression of dendritic cell function.
Sherven Sharma,Marina Stolina,Seok Chul Yang,Felicita Baratelli,Jeff F. Lin,Kimberly Calica Atianzar,Jie Luo,Li Zhu,Ying Lin,Min Huang,Mariam Dohadwala,Raj K. Batra,Steven M. Dubinett +12 more
TL;DR: It is concluded that inhibition of tumor COX-2 expression or activity can prevent tumor-induced suppression of DC activities and restore DC function and effective antitumor immune responses.
241
COX-2-dependent stabilization of survivin in non-small cell lung cancer
Kostyantyn Krysan,Farrukh H. Merchant,Li Zhu,Mariam Dohadwala,Jie Luo,Ying Lin,Nathalie Heuzé-Vourc'h,Mehis Põld,David Seligson,David Chia,Lee Goodglick,He-Jing Wang,Robert M. Strieter,Sherven Sharma,Steven M. Dubinett,Steven M. Dubinett +15 more
TL;DR: It was found that the expression of the anti‐apoptotic protein survivin correlated positively with COX‐2 expression and survivin and COx‐2 were frequently upregulated and co‐expressed in human lung cancers in situ.
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