Ying Li
Yale University
9 Papers
176 Citations
Ying Li is an academic researcher from Yale University. The author has contributed to research in topics: Orexin & Excitatory postsynaptic potential. The author has an hindex of 9, co-authored 9 publications.
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Papers
Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus
Anthony N. van den Pol,Prabhat K. Ghosh,Rong-Jian Liu,Ying Li,George K. Aghajanian,Xiao-Bing Gao +5 more
TL;DR: The hypothalamus, via hypocretin projections, may be in a position to enhance arousal and modulate plasticity in higher brain centres through the developing LC, as suggested by data from a new transgenic mouse with strong GFP expression in the LC.
173
μ-Opioid Receptor-Mediated Depression of the Hypothalamic Hypocretin/Orexin Arousal System
Ying Li,Anthony N. van den Pol +1 more
TL;DR: Together, these data are consistent with the view that the hypocretin system may be an important direct target for drugs of abuse, including opiates, that induce sedation and mental lethargy.
92
Enhanced Excitatory Input to Melanin Concentrating Hormone Neurons during Developmental Period of High Food Intake Is Mediated by GABA
Ying Li,AN van den Pol +1 more
TL;DR: During the early developmental period when food consumption is high, MCH neurons are more depolarized than in the adult, and an increased level of excitatory synaptic input to these orexigenic cells is mediated by GABA.
18
Reversed synaptic effects of hypocretin and NPY mediated by excitatory GABA-dependent synaptic activity in developing MCH neurons
TL;DR: Data for the first time show that both hypocretin and NPY receptors are functional presynaptically during early postnatal hypothalamic development and that both neuropeptides modulate GABA actions during development with a valence of enhanced excitation or inhibition opposite to that of the adult state, potentially allowing neuropePTide modulation of use-dependent synapse stabilization.
9
Group III Metabotropic Glutamate Receptors Maintain Tonic Inhibition of Excitatory Synaptic Input to Hypocretin/Orexin Neurons
TL;DR: The actions of group III metabotropic glutamate receptors (mGluRs) in modulating the activity of hypocretin neurons using whole-cell voltage- and current-clamp recording in mouse whole hypothalamic slices or minislices consisting only of the lateral hypothalamus suggest that tonically active inhibitory mGLURs are expressed on local hypoc retin-sensitive glutamate neurons within theateral hypothalamus that modulate the output of the hypocret in arousal system.