Ying Lan Jin
Wonkwang University
5 Papers
92 Citations
Ying Lan Jin is an academic researcher from Wonkwang University. The author has contributed to research in topics: Chalcone & Michael reaction. The author has an hindex of 4, co-authored 5 publications.
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Papers
Structural requirements of 2',4',6'-tris(methoxymethoxy) chalcone derivatives for anti-inflammatory activity: the importance of a 2'-hydroxy moiety.
Feng Jin,Xing Yu Jin,Ying Lan Jin,Dae Won Sohn,Soon-Ai Kim,Dong Hwan Sohn,Youn-Chul Kim,Hak Sung Kim +7 more
TL;DR: Investigation of the structural requirements of TMMC derivatives for anti-inflammatory effects modified the α,β-unsaturated ketone moiety through catalytic hydrogenation, hydride reduction, or introduction of a triple bond, and found the 2′-hydroxy group was crucial in increasing the anti- inflammatory effect.
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Structure activity relationship studies of anti-inflammatory TMMC derivatives: 4-dimethylamino group on the B ring responsible for lowering the potency.
TL;DR: Chalcone derivatives with various substituents on the A ring that showed potent anti-inflammatory effects by inhibiting NO production were synthesized and the 2′-hydroxy group was excluded because it could cause the formation of GSSG through a phenoxy radical and can confuse the interpretation of the biological results.
22
The first total synthesis of glycyrol
TL;DR: The first total synthesis of glycyrol was reported in this article, where the key steps are Smiles rearrangement and selective introduction of prenyl and O-methyl groups, and the introduction of a benzyl protecting group was important because selective deprotection was hard due to the low solubility of intermediates.
22
YL-I-108, a synthetic chalcone derivative, inhibits lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 murine macrophages: Involvement of heme oxygenase-1 induction and blockade of activator protein-1
TL;DR: Results indicate that YL-I-108 suppresses NO production in LPS-stimulated macrophages via simultaneous induction of HO-1 expression and blockade of AP-1 activation.
21
Structure-activity relationship studies of novel oxygen-incorporated SAHA analogues.
TL;DR: Novel oxygen-incorporated SAHA (oxa-SAHA) analogues, in which oxygen was inserted in the alkyl linker connecting the hydroxamic acid moiety and amide group, were synthesized and their inhibitory activities on histone deacetylase were evaluated.
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