11 Papers
16 Citations
Ying Hu is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Cathepsin C & Proteases. The author has an hindex of 9, co-authored 11 publications. Previous affiliations of Ying Hu include Veterans Health Administration.
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Papers
Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation
Huimin Yan,Hui-fang Zhou,Antonina Akk,Ying Hu,Luke E. Springer,Terri L. Ennis,Christine T. N. Pham +6 more
TL;DR: These results suggest that neutrophil protease–mediated NET release contributes to elastase-induced AAA through pDC activation and type I IFN production and suggest that limiting NET, pDC, and typeI IFN activities may suppress aneurysm progression.
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Neutrophil Serine Proteases Promote IL-1β Generation and Injury in Necrotizing Crescentic Glomerulonephritis
Adrian Schreiber,Christine T.N. Pham,Ying Hu,Wolfgang Schneider,Friedrich C. Luft,Ralph Kettritz,Ralph Kettritz +6 more
TL;DR: It is suggested that the development of anti-MPO antibody-induced NCGN requires NSP-dependent IL-1β generation and that these processes may provide therapeutic targets for ANCA-mediated diseases in humans.
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Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide
Hui Fang Zhou,Huimin Yan,Ying Hu,Luke E. Springer,Xiaoxia Yang,Samuel A. Wickline,Dipanjan Pan,Gregory M. Lanza,Christine T. N. Pham +8 more
TL;DR: Evidence is presented that Fum-PD nanotherapy indirectly suppresses inflammation in experimental RA through the local production of endothelial nitric oxide (NO) and reverses the suppression of NF-κB-mediated inflammatory response induced by Fum, PD nanotherapy.
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Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation
Huimin Yan,Hui-fang Zhou,Ying Hu,Christine T.N. Pham +3 more
- 28 Feb 2015
TL;DR: Findings establish a central role for autophagy in inflammatory arthritis and argue that Autophagy modulators such as metformin may represent potential therapeutic agents for the treatment of RA.
Fibrinogen-specific antibody induces abdominal aortic aneurysm in mice through complement lectin pathway activation
Hui-fang Zhou,Huimin Yan,Paula Bertram,Ying Hu,Luke E. Springer,Robert W. Thompson,John A. Curci,Dennis E. Hourcade,Christine T.N. Pham +8 more
TL;DR: Results support the concept that an autoimmune process directed at aortic wall self-antigens may play a central role in the immunopathogenesis of AAA and establish that alterations in the glycosylation patterns of this antibody critically affect its ability to activate theLP in vivo.
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